{"created":"2025-02-23T06:31:57.552782+00:00","id":2013391,"links":{},"metadata":{"_buckets":{"deposit":"2b223c2e-c1b9-44b4-89f0-69a6a1f96f97"},"_deposit":{"created_by":41,"id":"2013391","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2013391"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02013391","sets":["1727147343679:1730442224523:1730442306263"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Early Recognition of Patients with Decreased Methotrexate Clearance Following High-Dose Methotrexate Infusion Therapy","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ikeda, Hiroaki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Ikeda","familyNameLang":"en"}],"givenNames":[{"givenName":"Hiroaki","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kihira, Kenji","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kihira","familyNameLang":"en"}],"givenNames":[{"givenName":"Kenji","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kuwata, Naoharu","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kuwata","familyNameLang":"en"}],"givenNames":[{"givenName":"Naoharu","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Arai, Shigeaki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Arai","familyNameLang":"en"}],"givenNames":[{"givenName":"Shigeaki","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kimura, Yasuhiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kimura","familyNameLang":"en"}],"givenNames":[{"givenName":"Yasuhiro","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Miyake, Katsushi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Miyake","familyNameLang":"en"}],"givenNames":[{"givenName":"Katsushi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kitaura, Teruaki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kitaura","familyNameLang":"en"}],"givenNames":[{"givenName":"Teruaki","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Fujimura, Kingo","creatorNameLang":"en"}],"familyNames":[{"familyName":"Fujimura","familyNameLang":"en"}],"givenNames":[{"givenName":"Kingo","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kuramoto, Atsushi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kuramoto","familyNameLang":"en"}],"givenNames":[{"givenName":"Atsushi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Fukuchi, Hiroshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Fukuchi","familyNameLang":"en"}],"givenNames":[{"givenName":"Hiroshi","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"High-dose methotrexate infusion","subitem_subject_scheme":"Other"},{"subitem_subject":"Decreased clearance","subitem_subject_scheme":"Other"},{"subitem_subject":"Criterion","subitem_subject_scheme":"Other"},{"subitem_subject":"Drug monitoring","subitem_subject_scheme":"Other"},{"subitem_subject":"Renal function","subitem_subject_scheme":"Other"},{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"The purpose of this study was to identify the patients with decreased methotrexate (MTX) clearance as early as possible after the start of high-dose methotrexate (HD-MTX) infusion. Fifty-six patients (age: 18~83 years) received a HD-MTX infusion (dosage: 1.9~3.8 g/m2) for 6 h. These patients were retrospectively divided into a low-clearance group and a high-clearance group based on the serum MTX concentration at 48 h (1 μM). Six out of the 56 patients showed decreased MTX clearance. The MTX concentrations in the low-clearance group were significantly higher than those in the high-clearance group even in earlier sampling times than at 48 h. The average MTX concentrations were 330 μM at 6 h, 72 μM at 12 h, and 16 μM at 24 h in the low-clearance group, and those in the high-clearance group were 210 μM, 18 μM, and 1.0 μM, respectively. The estimated elimination half-lives (t1/2) at 6~12 h and 12 ~ 24 h after the start of the infusion were also significantly longer in the low-clearance group (2.8 vs. 1.7 h and 5.0 vs. 2.8 h, respectively). Therefore, we proposed convenient criteria based on the mean + 1 S.D. of the high-clearance group: the concentration > 270 μM at 6 h and > 32 μM at 12 h; the t1/2 value > 2.1 h at 6~12 h. All 6 patients were recognized as belonging to the low-clearance group at an early stage after HD-MTX infusion by using our proposed criteria. These results indicate that patients with decreased MTX clearance could be identified within the first 12 h after the start of HD-MTX infusion. The factors influencing the prolonged elimination of MTX were also investigated. A significant decrease in renal function on day 2 was observed in the low-clearance group. The MTX level at 12 h and the estimated t1/2 values were significantly correlated with BUN, Ser and Clcr on the 2nd day after HD-MTX therapy, suggesting that an alteration in renal function occurs within 12 h of the HD-MTX infusion. The prolonged elimination of MTX could be attributable to this decrease in renal function.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Hiroshima University Medical Press"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0018-2052","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00664312","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"開始ページ","attribute_value_mlt":[{"subitem_start_page":"57"}]},"item_1617187056579":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1996-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"62","bibliographicPageStart":"57","bibliographicVolumeNumber":"45","bibliographic_titles":[{"bibliographic_title":"Hiroshima Journal of Medical Sciences"},{"bibliographic_title":"Hiroshima Journal of Medical Sciences"}]}]},"item_1617258105262":{"attribute_name":"item_1617258105262","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"HiroshimaJMedSci_45_57.pdf","filesize":[{"value":"526.0 KB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2013391/files/HiroshimaJMedSci_45_57.pdf"},"version_id":"f1304efe-7b21-44b0-a108-696a6b075936"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"37841"},"item_title":"Early Recognition of Patients with Decreased Methotrexate Clearance Following High-Dose Methotrexate Infusion Therapy","item_type_id":"40003","owner":"41","path":["1730442306263"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2013391","relation_version_is_last":true,"title":["Early Recognition of Patients with Decreased Methotrexate Clearance Following High-Dose Methotrexate Infusion Therapy"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-06-02T03:08:10.227659+00:00"}