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Dietary NaCl Loading Increases Platelet Ca2+ Discharge Capacity in Salt Resistant Essential Hypertension
https://hiroshima.repo.nii.ac.jp/records/2013386
https://hiroshima.repo.nii.ac.jp/records/2013386f1e7f832-208a-42b8-9195-83522b7a5963
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HiroshimaJMedSci_45_23.pdf (820.0 KB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||
| タイトル | ||||||||
| タイトル | Dietary NaCl Loading Increases Platelet Ca2+ Discharge Capacity in Salt Resistant Essential Hypertension | |||||||
| 言語 | en | |||||||
| 作成者 |
Watanabe, Mitsuaki
× Watanabe, Mitsuaki
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| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Salt sensitivity | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Calcium | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Platelet | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Essential hypertension | |||||||
| 主題 | ||||||||
| 主題Scheme | NDC | |||||||
| 主題 | 490 | |||||||
| 内容記述 | ||||||||
| 内容記述 | To clarify the relationship between cellular Ca2+ handling and salt sensitivity, we evaluated cytosolic free Ca2+ ([Ca2+]i) in fura-2 loaded platelets isolated from 20 inpatients with essential hypertension. They were placed on a low sodium diet (50 mmol/day) for one week, followed by one week on a high sodium diet (340 mmol/day). They were classified into salt-sensitive (SS, n=8) or salt-resistant (SR, n=12) based on changes in the mean blood pressure. During the low salt diet, basal [Ca2+]i, thrombin-evoked maximal Ca2+ responses, irrespective of the presence of 1 mM extracellular Ca2+, and ionomycin-sensitive intracellular Ca2+ discharge capacity were similar in salt-sensitive and salt-resistant patients. Platelet basal [Ca2+]i were increased in both groups by salt loading (SS, from 22.0±1.3 to 27.2±1.9 nM, p<0.01; SR, from 20.1±0.8 to 24.4±1.3 nM, p<0.05). The thrombin-evoked maximal Ca2+ responses both in the presence and absence of extracellular Ca2+ were unchanged by high salt intake. The rate constant of decline in Ca2+ after the peak response to thrombin was larger in SR than that in SS during the high salt diet period (SS, 0.004 ± 0.001 sec-1; SR, 0.043 ± 0.014 sec-1, p<0.05). The intracellular Ca2+ discharge capacity was increased by excessive salt intake in the salt-resistant patients but was unchanged in the salt-sensitive patients (SS, from 658. l ± 52.8 to 639.6 ± 91.9 nM; SR, from 690.8 ± 65.1 to 803.3 ± 65.1 nM, p<0.05). An increased intracellular Ca2+ discharge capacity may play, at least in part, a significant role in preventing the elevation of blood pressure after salt loading in salt-resistant patients with essential hypertension. | |||||||
| 言語 | en | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | This paper was presented in part at 49th Annual Fall Conference and Scientific Sessions of the Council for High Blood Pressure Research, New Orleans, Louisiana, September 19-22, 1995 | |||||||
| 出版者 | ||||||||
| 出版者 | Hiroshima University Medical Press | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | departmental bulletin paper | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 0018-2052 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AA00664312 | |||||||
| 開始ページ | ||||||||
| 開始ページ | 23 | |||||||
| 書誌情報 |
Hiroshima Journal of Medical Sciences Hiroshima Journal of Medical Sciences 巻 45, 号 1, p. 23-30, 発行日 1996-03 |
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| 旧ID | 37836 | |||||||
