| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Serum and Urinary Type IV Collagen Concentrations in the Assessment of Diabetic Microangiopathy |
|
言語 |
en |
| 作成者 |
Banu, Nazifa
Hara, Hitoshi
Egusa, Genshi
Yamakido, Michio
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Type IV collagen |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Diabetic nephropathy |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Diabetic retinopathy |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Non-diabetic renal disease |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
We investigated the role of measurement of serum and urinary type IV collagen (IV-C) levels in monitoring diabetic microangiopathy. Furthermore, we compared these levels in diabetic nephropathy and non-diabetic renal disease (NDRD). A one-step sandwich enzyme immunoassay was used to measure IV-C levels in 82 diabetic patients, 33 NDRD patients and 20 healthy non-diabetic control subjects. The diabetic patients were classified into four groups according to urinary albumin I creatinine index CACI) (mg/g) and serum creatinine (s-Cr) (mg/dl) : normoalbuminuria (ACI<30), microalbuminuria (ACI 30-300), albuminuria (ACI >300, s-Cr<l.99 mg/dl) and renal insufficiency (s-Cr>l.99 mg/dl). Serum and urinary IV-C levels were significantly elevated even in diabetic patients without clinical evidence of microangiopathy compared with control subjects (p<0.05 and p<0.01, respectively). Both levels were significantly higher in normoalbuminuric patients than in the control subjects, and in patients with microalbuminuria, albuminuria or renal insufficiency than in normoalbuminuric patients, with significant differences between these groups (serum and urinary IV-C, both p<0.0001 by ANOVA). Urinary IV-C and albumin levels were significantly correlated, even in normo- and microalbuminuric patients (r = 0.55, p<0.0001). Serum IV-C in normoalbuminuric patients rose significantly as the degree of retinopathy progressed from background to proliferative stages (p<0.05). Neither serum nor urinary IV-C levels were influenced by glycemic control. Albuminuric diabetic patients (with and without renal insufficiency) had significantly higher levels of serum IV-C compared with those in proteinuric NDRD patients (p<0.005), though there was no significant difference in the urinary IV-C level. However, the urinary IV-CI albumin ratio was significantly higher in albuminuric diabetic patients than in proteinuric NDRD patients, even after adjusting for s-Cr and creatinine clearance (p<0.0001). In conclusion, we suggest that measured serum and urinary IV-C concentrations may serve as new markers for monitoring the development and progression of diabetic microangiopathy, particularly nephropathy. Furthermore, the measurement of serum IV-C concentrations and urinary IV-CI albumin ratios in diabetic patients may allow diabetic nephropathy and non-diabetic renal disease to be differentiated. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
A part of this work was presented at the 36th annual meeting of the Japan Diabetes Society (Sendai, Japan, May 13-15, 1993), and another part has been accepted for presentation at the 15th International Diabetes Federation Congress (Kobe, Japan, November 6-11, 1994). |
| 出版者 |
|
|
出版者 |
Hiroshima University Medical Press |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0018-2052 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00664312 |
| 開始ページ |
|
|
開始ページ |
123 |
| 書誌情報 |
Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences
巻 43,
号 4,
p. 123-133,
発行日 1994-12
|
| 旧ID |
37891 |
HiroshimaJMedSci_43_123.pdf (1.2 MB)
