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Studies on Autoimmune Mechanisms of Thyroglobulin Autoantibody in Autoimmune Thyroid Disease
https://hiroshima.repo.nii.ac.jp/records/2013337
https://hiroshima.repo.nii.ac.jp/records/2013337ba76cc38-52b5-4c28-adee-56dfd35cb8b8
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HiroshimaJMedSci_43_1.pdf (1.1 MB)
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| アイテムタイプ | デフォルトアイテムタイプ_（フル）(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||
| タイトル | ||||||||
| タイトル | Studies on Autoimmune Mechanisms of Thyroglobulin Autoantibody in Autoimmune Thyroid Disease | |||||||
| 言語 | en | |||||||
| 作成者 |
Xiu, Ling Ling
× Xiu, Ling Ling
|
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| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Autoimmune thyroid disease | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Anti-thyroglobulin autoantibody | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Anti-idiotypic antibody | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | IgG-subclass | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Soluble IL-2 receptor | |||||||
| 主題 | ||||||||
| 主題Scheme | NDC | |||||||
| 主題 | 490 | |||||||
| 内容記述 | ||||||||
| 内容記述 | In order to clarify the autoimmune mechanisms of anti-Tg antibody (anti-TgAb) in autoimmune thyroid disease (AITD), a series of examinations were conducted in patients with Graves' disease (n=59), Hashimoto's thyroiditis (n=63) and healthy controls (n=38). Our findings can be summarized as follows: 1) The distribution of anti-TgAb was measured by IgG subclass ELISA. IgG1 and/or IgG4 antibodies formed the major anti-Tg response, but in some patients, IgG2 anti-Tg tend to be the predominant response. We used ELISA to determine an IgG1 anti-Tg bound to Tg that had already interacted with IgG2 Tg-antibody (and vice versa). The results substantiated the view that TgAb of a different IgG subclass interacts with different epitopes on Tg. 2) Human antiidiotypic (anti-Id) antibodies to anti-Tg antibody occur spontaneously in the AITD. These anti-Id antibodies can be divided into two categories based on properties of their binding sites. One type acts like a 'internal image' of Tg antigen which shown Ab2β activity. Another type has Ab2α activity that recognizes Id determinants in the framework region common among anti-Tg antibody. 3) We also examined the competitive binding assay between TgAb and TgAb F(ab')2 fragments, and demonstrated differences in the TgAb repertoires between patients. 4) Soluble IL-2 receptor (IL-2R) of patients significantly increased as compared with normal subjects and IL-2R values in GD were higher than those in HT (p<0.001). Therefore, IL-2R is regarded as a useful marker for disease activity. | |||||||
| 言語 | en | |||||||
| 出版者 | ||||||||
| 出版者 | Hiroshima University Medical Press | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | departmental bulletin paper | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 0018-2052 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AA00664312 | |||||||
| 開始ページ | ||||||||
| 開始ページ | 1 | |||||||
| 書誌情報 |
Hiroshima Journal of Medical Sciences Hiroshima Journal of Medical Sciences 巻 43, 号 1, p. 1-11, 発行日 1994-03 |
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| 旧ID | 37876 | |||||||
