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Circadian Variation of 5-Fluorouracil and Cis-Platinum Toxicity in Mice
https://hiroshima.repo.nii.ac.jp/records/2013333
https://hiroshima.repo.nii.ac.jp/records/20133337f0f6c77-a8cb-41a9-8fcb-a0d2a511d32d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HiroshimaJMedSci_42_147.pdf (803.8 KB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Circadian Variation of 5-Fluorouracil and Cis-Platinum Toxicity in Mice | |||||||||||
| 言語 | en | |||||||||||
| 作成者 |
Shakil, Abdus
× Shakil, Abdus
× Hirabayashi, Naoki
× Toge, Tetsuya
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| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Circadian rhythm | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Chemotherapy | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Anticancer agents | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Toxicity | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Dosing time | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | NDC | |||||||||||
| 主題 | 490 | |||||||||||
| 内容記述 | ||||||||||||
| 内容記述 | Circadian variations of organ specific and lethal toxicities were investigated in fem ale C3H mice following intraperitoneal injection(s) of 5-fluorouracil (5-FU) and/or cis-platinum (CDDP) with different doses at one of the four equidistant time points, viz., 3, 9, 15 and 21 HALO (Hours After Light On). Lethality, peripheral WBC count, spleen size, femoral bone marrow cell population and changes in body weight were analyzed. A single injection of 5-FU (300 mg/kg) showed 45% mortality with 3 HALO and 15% with 9 HALO treatment (p<0.05); that with CDDP (16 mg/kg) was 80% in 3 HALO and 10% in 9 HALO group (p<0.01). Peripheral WBC count on the 4th post-treatment day showed that drug induced leukopenia was less severe with 15 HALO dosing compared to the other HALO points (p<0.01). The reduction in spleen size following treatment was maximum in 3 HALO treated group with both drugs (p<0.01). The combination therapy of these two drugs also showed circadian variation of toxicity. The results suggest that the toxic effects of chemotherapy are dosing time dependent. | |||||||||||
| 言語 | en | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | Hiroshima University Medical Press | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| 収録物識別子 | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 0018-2052 | |||||||||||
| 収録物識別子 | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AA00664312 | |||||||||||
| 開始ページ | ||||||||||||
| 開始ページ | 147 | |||||||||||
| 書誌情報 |
Hiroshima Journal of Medical Sciences Hiroshima Journal of Medical Sciences 巻 42, 号 4, p. 147-154, 発行日 1993-12 |
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| 旧ID | 37930 | |||||||||||
