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Modulation of Sodium Channel Activity in Frog Ventricular Cells by Guanidyl-side Armed Cyclam
https://hiroshima.repo.nii.ac.jp/records/2013304
https://hiroshima.repo.nii.ac.jp/records/2013304f9eb781f-9fc6-41dd-8681-92ac3651cf54
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HiroshimaJMedSci_41_49.pdf (689.4 KB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||
| タイトル | ||||||||
| タイトル | Modulation of Sodium Channel Activity in Frog Ventricular Cells by Guanidyl-side Armed Cyclam | |||||||
| 言語 | en | |||||||
| 作成者 |
Yakehiro, Masuhide
× Yakehiro, Masuhide
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| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Sodium channel | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Polyamine | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Frog ventricular cells | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Block | |||||||
| 主題 | ||||||||
| 主題Scheme | NDC | |||||||
| 主題 | 490 | |||||||
| 内容記述 | ||||||||
| 内容記述 | The mechanism underlying the Na channel blocking action of guanidyl-side armed cyclam (G-cyclam) was studied using conventional patch-clamp methods. G-cyclam applied to the cytoplasmic surface of the membrane reduced the amplitude of single Na channel currents without inducing a flickering block. This effect was enhanced by depolarization and was fully reversible upon washout of the drug. The relationship between the concentration of G-cyclam and the reduction of unitary current could be expressed mathematically assuming one-to-one stoichiometry. During maximal suppression of the single channel current by G-cyclam approximately 40% of the current remained. Low concentration of G-cyclam (3×10-4M) prolonged, while higher concentration (3×10-3M) shortened the mean open time suggesting the involvement of two processes in the Na channel blocking action of this agent. It appears that low concentration of G-cyclam induce rapid and frequent transition between open and less conductive state resulting in a reduced current, and higher concentration make the channel nonconductive with slower single channel kinetics. | |||||||
| 言語 | en | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | This work was supported in part by a Grant-in-Aid from the Ministry of Education, Science and Culture of Japan and a grant from the Tsuchiya Foundation. | |||||||
| 出版者 | ||||||||
| 出版者 | Hiroshima University Medical Press | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | departmental bulletin paper | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 関連情報 | ||||||||
| 識別子タイプ | PMID | |||||||
| 関連識別子 | 1338064 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 0018-2052 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AA00664312 | |||||||
| 開始ページ | ||||||||
| 開始ページ | 49 | |||||||
| 書誌情報 |
Hiroshima Journal of Medical Sciences Hiroshima Journal of Medical Sciences 巻 41, 号 3, p. 49-55, 発行日 1992-09 |
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| 旧ID | 37943 | |||||||
