| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Studies on the Effectiveness of Sairei-to on Puromycin Aminonucleoside Nephrosis in Rats |
|
言語 |
en |
| 作成者 |
Joarder, Zahid Hossain
Ogawa, Takahiko
Yorioka, Noriaki
Yamakido, Michio
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Sairei-to |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Puromycin aminonucleoside |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Nephrotic syndrome |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Superoxide dismutase |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Pros tag Jan dins |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
In order to assess the effectiveness of sairei-to on nephrosis and to elucidate its mechanism of action, we made a puromycin aminonucleoside (PAN) rat model by a single intra-peritoneal injection of PAN at a dose of 100mg/kg body weight (B.W.) and compared it to the normal controls. Sairei-to was administered in various doses (100,200,500mg/kg B.W.) orally for 8 days after the initial injection of PAN. Proteinuria and serum triglyceride levels were significantly reduced in the sairei-to-treated groups which had been pretreated with PAN. Light and electron microscopically sairei-to-treated groups showed a morphological improvement in the kidney over the PAN group. We found 500mg/kg B.W. of sairei-to to be the most effective dose. The superoxide dismutase (SOD)-like activity was significantly elevated in the serum but not changed in the urine of sairei-to-treated groups pretreated with PAN. The normal control fed with 500mg/kg B.W. of sairei-to showed a significant increase in serum SOD-like activity. The urinary prostanoid levels in the PAN group were lower than those in the normal and sairei-to-treated groups. These results support our hypothesis that sairei-to has effects on the elevation of SOD-like activity and on the synthesis of prostanoid in PAN-induced nephrosis, and that these effects are responsible for the mechanism of action of sairei-to. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Parts of this work were presented at the 32nd Annual Meeting of the Japanese Society of Nephrology, November 9-11, 1989, Hamamatsu, Japan; the 20th Western Annual Meeting of the Japanese Society of Nephrology, April 26-27, 1990, Okayama, Japan; the 6th International Congress of Oriental Medicine, October 19-21, 1990, Tokyo, Japan, and the 21st Western Annual Meeting of the Japanese Society of Nephrology, May 31-June 1, 1991, Kobe, Japan. |
| 出版者 |
|
|
出版者 |
Hiroshima University Medical Press |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
1797743 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0018-2052 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00664312 |
| 開始ページ |
|
|
開始ページ |
127 |
| 書誌情報 |
Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences
巻 40,
号 4,
p. 127-135,
発行日 1991-12
|
| 旧ID |
38026 |
HiroshimaJMedSci_40_127.pdf (1.5 MB)
