| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
β-lactamase in Gram-negative Rods : the relationship between penicillinase and R plasmids in Gram-negative rods |
|
言語 |
en |
| 作成者 |
Takesue, Yoshio
Yokoyama, Takashi
Kodama, Takashi
Murakami, Yoshiaki
Sewake, Hitoshi
Miyamoto, Katsunari
Imamura, Yuuji
Tsumura, Hiroaki
Matsuura, Yuichiro
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
β-lactamase |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
R plasmid |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Antibiotic resistance |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Chemotherapeutic agents |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Concomitant with the extensive use of antibiotics, the number of multiple antibiotic-resistant strains has been increasing. Since resistance is mainly mediated by R plasmids, we undertook to investigate the characteristics of R plasmid-determined ,β-lactamase in 6 Gram-negative rods. The β-lactamase produced by each organism was classified by its substrate: type P which attacks penicillins, type C which attacks cephalosporins, and type C/P which attacks both penicillins and cephalosporins. Though the chromosomally mediated β-lactamase of almost all Gram-negative rods is classified as type C, R plasmid-mediated β-lactamase is almost equally active against both penicillins and cephalosporins. Therefore, we suggest that type C/P ,β-lactamase was mediated by R plasmids in Gram-negative rods which already produced chromosomally mediated type C β-lactamase. The strains which produced type C/P β-lactamse tended to be more resistant to antibiotics than the other β-lactamase producing strains. Among type C/P strains, the sensitivity to cephalosporins varied with the bacterial species, whereas all these strains were highly resistant to penicillins. Even for piperacillin, which is stable to cephalosporinase, the MIC at which the cumulative percentage of strains inhibited was 50% (MIC50) was over 50 μg/ml in all strains tested. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Hiroshima University Medical Press |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
2126540 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0018-2052 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00664312 |
| 開始ページ |
|
|
開始ページ |
65 |
| 書誌情報 |
Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences
巻 39,
号 3,
p. 65-69,
発行日 1990-09
|
| 旧ID |
38079 |
HiroshimaJMedSci_39_65.pdf (409.4 KB)
