{"created":"2025-02-23T06:27:49.159690+00:00","id":2013250,"links":{},"metadata":{"_buckets":{"deposit":"c3671dee-b71f-4b40-a847-fae1f8355770"},"_deposit":{"created_by":41,"id":"2013250","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2013250"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02013250","sets":["1727147343679:1730442224523:1730442324188"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Effects of ATP Depletion with DL-Ethionine on Biliary Excretion of Indocyanine Green in the Rat","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shiba, Yoshiki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Shiba","familyNameLang":"en"}],"givenNames":[{"givenName":"Yoshiki","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kanno, Yoshinobu","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kanno","familyNameLang":"en"}],"givenNames":[{"givenName":"Yoshinobu","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"ATP depletion","subitem_subject_scheme":"Other"},{"subitem_subject":"Biliary excretion","subitem_subject_scheme":"Other"},{"subitem_subject":"Liver","subitem_subject_scheme":"Other"},{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"To clarify the energy-dependency of biliary excretion of a diagnostic dye, the effect of ATP depletion on biliary excretion was investigated. Biliary excretion of indocyanine green (ICG) in rat liver reached a maximum 20 min after intravenous application. The level of ATP in the liver was lowered to 35.4% of the control value about 5 h after administration of DL-ethionine (100 mg/100 g body weight). The rate of bile flow and the amount of ICG excreted in initial 10 min into the bile of ethionine-treated rats were lowered to 67.5% and 61.3% of the control values, respectively. The amount of ICG excreted for 10 min from 30 min to 40 min after application of ICG in ethionine-treated rats was comparable to that of the control. The level of ICG in blood 5 min after application of ICG was raised by 59.2% of the control value. These results suggest that ATP depletion in the liver caused by treatment with ethionine suppresses the initial rate of uptake and biliary excretion of ICG.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Hiroshima University Medical Press"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0018-2052","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00664312","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"開始ページ","attribute_value_mlt":[{"subitem_start_page":"11"}]},"item_1617187056579":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1990-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"14","bibliographicPageStart":"11","bibliographicVolumeNumber":"39","bibliographic_titles":[{"bibliographic_title":"Hiroshima Journal of Medical Sciences"},{"bibliographic_title":"Hiroshima Journal of Medical Sciences"}]}]},"item_1617258105262":{"attribute_name":"item_1617258105262","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"2373637","subitem_relation_type_select":"PMID"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"HiroshimaJMedSci_39_11.pdf","filesize":[{"value":"391.9 KB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2013250/files/HiroshimaJMedSci_39_11.pdf"},"version_id":"95778c7b-ae27-4e30-a3fd-5d3e74d39389"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"38032"},"item_title":"Effects of ATP Depletion with DL-Ethionine on Biliary Excretion of Indocyanine Green in the Rat","item_type_id":"40003","owner":"41","path":["1730442324188"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2013250","relation_version_is_last":true,"title":["Effects of ATP Depletion with DL-Ethionine on Biliary Excretion of Indocyanine Green in the Rat"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-06-02T03:01:23.631175+00:00"}