{"created":"2025-02-23T06:27:35.247251+00:00","id":2013242,"links":{},"metadata":{"_buckets":{"deposit":"773435ac-c63a-4852-8dd8-2668b2867ae2"},"_deposit":{"created_by":41,"id":"2013242","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2013242"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02013242","sets":["1727147343679:1730442224523:1730442325010"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"The Effect of Phorbol Esters on Cell Growth and Epidermal Growth Factor Receptor Modulation in a Human Gastric Carcinoma Cell Line TMK-1","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ochiai, Atsushi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Ochiai","familyNameLang":"en"}],"givenNames":[{"givenName":"Atsushi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yasui, Wataru","creatorNameLang":"en"}],"familyNames":[{"familyName":"Yasui","familyNameLang":"en"}],"givenNames":[{"givenName":"Wataru","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kameda, Takashi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kameda","familyNameLang":"en"}],"givenNames":[{"givenName":"Takashi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Takanashi, Atsushi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Takanashi","familyNameLang":"en"}],"givenNames":[{"givenName":"Atsushi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Takekura, Naoki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Takekura","familyNameLang":"en"}],"givenNames":[{"givenName":"Naoki","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tahara, Eiichi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Tahara","familyNameLang":"en"}],"givenNames":[{"givenName":"Eiichi","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Phorbol ester","subitem_subject_scheme":"Other"},{"subitem_subject":"Protein kinase C","subitem_subject_scheme":"Other"},{"subitem_subject":"Gastric cancer cell","subitem_subject_scheme":"Other"},{"subitem_subject":"EGF receptor","subitem_subject_scheme":"Other"},{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Tumor promoting phorbol esters, 12-O-tetradecanoylphorbol-13-acetate (TPA) and phorbol-12, 13-dibutyrate (PDBu), significantly enhanced the growth of human gastric cancer cell line TMK-1, whilst activating protein kinase C. The time course of 125I-epidermal growth factor (EGF) binding to TMK-1 cells after TPA treatment showed a decrease in the number of EGF receptors on TMK-1 cells within 3 hr. Autophosphorylation of EGF receptor decreased in accordance with the decrease of EGF binding by TPA treatment. Scatchard plot analysis of TMK-1 cells after TPA treatment showed that high affinity EGF receptor disappeared at 3hr but the number of EGF receptors increased at 24 hr. These findings suggest that tumor promoting phorbol esters stimulate the cell growth through activation of protein kinase C and modification of EGF receptor of human gastric cancer cell line TMK-1.","subitem_description_language":"en"},{"subitem_description":"This research was supported in part by Grants-in Aid for Cancer Research from the Ministry of Education, Science and Culture of Japan and from the Ministry of Health and Welfare for a Comprehensive 10-Year Strategy for Cancer Control, Japan.","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Hiroshima University Medical Press"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0018-2052","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00664312","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"開始ページ","attribute_value_mlt":[{"subitem_start_page":"191"}]},"item_1617187056579":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1989-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"195","bibliographicPageStart":"191","bibliographicVolumeNumber":"38","bibliographic_titles":[{"bibliographic_title":"Hiroshima Journal of Medical Sciences"},{"bibliographic_title":"Hiroshima Journal of Medical Sciences"}]}]},"item_1617258105262":{"attribute_name":"item_1617258105262","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"2637248","subitem_relation_type_select":"PMID"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"HiroshimaJMedSci_38_191.pdf","filesize":[{"value":"349.6 KB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2013242/files/HiroshimaJMedSci_38_191.pdf"},"version_id":"fad027c7-5f63-4568-b724-70778312a048"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"38130"},"item_title":"The Effect of Phorbol Esters on Cell Growth and Epidermal Growth Factor Receptor Modulation in a Human Gastric Carcinoma Cell Line TMK-1","item_type_id":"40003","owner":"41","path":["1730442325010"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2013242","relation_version_is_last":true,"title":["The Effect of Phorbol Esters on Cell Growth and Epidermal Growth Factor Receptor Modulation in a Human Gastric Carcinoma Cell Line TMK-1"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-06-02T03:00:55.209477+00:00"}