{"created":"2025-02-23T06:27:29.586019+00:00","id":2013239,"links":{},"metadata":{"_buckets":{"deposit":"d2046167-1f35-4e21-a0d7-d607f47d0b15"},"_deposit":{"created_by":41,"id":"2013239","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2013239"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02013239","sets":["1727147343679:1730442224523:1730442325010"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"A Pharmacological Study of Veratrine-Induced Hyperthermia in the Rat : A Model of Neuroleptic Malignant Syndrome","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kato, Tadahiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kato","familyNameLang":"en"}],"givenNames":[{"givenName":"Tadahiro","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yamawaki, Shigeto","creatorNameLang":"en"}],"familyNames":[{"familyName":"Yamawaki","familyNameLang":"en"}],"givenNames":[{"givenName":"Shigeto","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Dopamine","subitem_subject_scheme":"Other"},{"subitem_subject":"Serotonin","subitem_subject_scheme":"Other"},{"subitem_subject":"Veratrine","subitem_subject_scheme":"Other"},{"subitem_subject":"Neuroleptic malignant syndmme","subitem_subject_scheme":"Other"},{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Stereotaxic microinjection of veratrine (50 μg in 1 μl of saline) into the preoptic anterior hypothalamus of rats which were intraperitoneally pretreated with haloperidol (1 mg/kg), significantly elevated body temperature (1.4 °C above normal body temperature) and produced abnormal behaviors. This microinjection also facilitated turnover of dopamine and serotonin in the regions of the thalamus and hypothalamus. Hyperthermia induced by haloperidol plus veratrine was significantly inhibited by systemic administration of serotonin antagonists (cyproheptadine 10 mg/kg, ritanserin 3 mg/kg). These findings suggest that hyperthermia in neuroleptic malignant syndrome is due to the dominant effect of serotonin in the thermoregulatory center either by blocking the dopamine receptor or by enhancing the serotonin secretion.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Hiroshima University Medical Press"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0018-2052","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00664312","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"開始ページ","attribute_value_mlt":[{"subitem_start_page":"173"}]},"item_1617187056579":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1989-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"181","bibliographicPageStart":"173","bibliographicVolumeNumber":"38","bibliographic_titles":[{"bibliographic_title":"Hiroshima Journal of Medical Sciences"},{"bibliographic_title":"Hiroshima Journal of Medical Sciences"}]}]},"item_1617258105262":{"attribute_name":"item_1617258105262","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"2637245","subitem_relation_type_select":"PMID"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"HiroshimaJMedSci_38_173.pdf","filesize":[{"value":"454.1 KB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2013239/files/HiroshimaJMedSci_38_173.pdf"},"version_id":"f27dc6c0-795a-4c23-aad3-1ceac50146d5"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"38127"},"item_title":"A Pharmacological Study of Veratrine-Induced Hyperthermia in the Rat : A Model of Neuroleptic Malignant Syndrome","item_type_id":"40003","owner":"41","path":["1730442325010"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2013239","relation_version_is_last":true,"title":["A Pharmacological Study of Veratrine-Induced Hyperthermia in the Rat : A Model of Neuroleptic Malignant Syndrome"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-06-02T03:00:55.756848+00:00"}