| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
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|
タイトル |
Effects of a Diphenyl Ether Herbicide (CNP Emulsion) on Mouse Fetuses |
|
言語 |
en |
| 作成者 |
Hiraoka, Yukio
Imada, Atsushi
Tanaka, Junko
Okuda, Hisanori
|
| アクセス権 |
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|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 主題 |
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主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
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|
内容記述 |
We investigated the effects of a diphenyl ether herbicide, a chlornitrophen (CNP) emulsion, on mouse fetuses. An MO emulsion was used as the experimental chemical twenty percent of this herbicide consisting of CNP. CNP and other components were extracted and evaporated (undegraded solution). The chemical was diluted 10 times by deionized water and then exposed to sunlight until the CNP concentration in the mixture became 10% of the initial CNP concentration. CNP, degradation products, and other materials were extracted from the mixture and evaporated (degraded solution). The undegraded and degraded solutions were administered subcutaneously to the backs of pregnant mice from the 6th to 15th fetal day, once daily. The mice were sacrificed on the 18th day of pregnancy. The number of fetuses and implantations, their weights, externals and skeletons were observed. Infant mice born from maternal mice treated in the same way as above were weighed once a week. Mean fetal body weights of the undegraded and degraded solution dose groups were significantly lower than those of the control (p < 0.001). Fetal skeletal abnormalities were also higher than those of the control. The degraded solution dose group differed particularly in this regard from the control (p < 0.05). In the degraded solution dose group, all 21 newborn infants from two maternal mice out of a total of 43 newborn infants from four maternal mice died within one week. The above results suggest that the degraded solution of CNP is no less noxious on mouse fetuses than the undegraded solution. Thus, more consideration should be given not only to the original chemicals but to the degradation products as well when assessing agricultural control chemicals for their safety. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
This study was supported by a Grant-in-Aid for General Scientific Research from the Ministry of Education, Science, and Culture of Japan (63570238). |
| 出版者 |
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|
出版者 |
Hiroshima University Medical Press |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
2584056 |
| 収録物識別子 |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0018-2052 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00664312 |
| 開始ページ |
|
|
開始ページ |
125 |
| 書誌情報 |
Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences
巻 38,
号 3,
p. 125-129,
発行日 1989-09
|
| 旧ID |
38118 |
HiroshimaJMedSci_38_125.pdf (309.2 KB)
