{"created":"2025-02-23T06:27:07.422155+00:00","id":2013226,"links":{},"metadata":{"_buckets":{"deposit":"f4390369-e9fe-4752-b4b5-771ee73b6f09"},"_deposit":{"created_by":41,"id":"2013226","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2013226"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02013226","sets":["1727147343679:1730442224523:1730442325569"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Antitumor Effect of Recombinant Human Lymphotoxin on a Tumor Line of Human Malignant Glioma","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mikami, Takashi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Mikami","familyNameLang":"en"}],"givenNames":[{"givenName":"Takashi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kurisu, Kaoru","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kurisu","familyNameLang":"en"}],"givenNames":[{"givenName":"Kaoru","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kiya, Katsuzo","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kiya","familyNameLang":"en"}],"givenNames":[{"givenName":"Katsuzo","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Mukada, Kazutoshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Mukada","familyNameLang":"en"}],"givenNames":[{"givenName":"Kazutoshi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kawamoto, Keiichi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kawamoto","familyNameLang":"en"}],"givenNames":[{"givenName":"Keiichi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hotta, Takuhiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"Hotta","familyNameLang":"en"}],"givenNames":[{"givenName":"Takuhiro","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Uozumi, Tohru","creatorNameLang":"en"}],"familyNames":[{"familyName":"Uozumi","familyNameLang":"en"}],"givenNames":[{"givenName":"Tohru","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Lymphotoxin","subitem_subject_scheme":"Other"},{"subitem_subject":"Tumor necrosis factor","subitem_subject_scheme":"Other"},{"subitem_subject":"Glioma","subitem_subject_scheme":"Other"},{"subitem_subject":"Xenotransplantable tumor","subitem_subject_scheme":"Other"},{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"We examined the antitumor effect of recombinant human lymphotoxin (rHuLT) on a xenotransplantable human malignant glioma line. Tumor-bearing nude mice were treated with rHuLT for three weeks following four schedules: intratumoral injection of rHuLT 20,000 units once a week, twice a week, intravenous injection once a week and twice a week. The inhibition rate of tumor growth was 98.8%, 99.1 %, 92.1 % and 98.8%, respectively. Histologically, necrotic lesions were observed in the tumors of all treated mice. Thrombo-obstructive changes of tumor vessels were also seen in the tumors of mice after intravenous injection of rHuLT. None of the mice died as a result of this treatment in spite of significant body weight loss. These results indicate that rHuLT has a strong antitumor effect on a xenotransplantable human malignant glioma line.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Hiroshima University Medical Press"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0018-2052","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00664312","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"開始ページ","attribute_value_mlt":[{"subitem_start_page":"103"}]},"item_1617187056579":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1989-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"107","bibliographicPageStart":"103","bibliographicVolumeNumber":"38","bibliographic_titles":[{"bibliographic_title":"Hiroshima Journal of Medical Sciences"},{"bibliographic_title":"Hiroshima Journal of Medical Sciences"}]}]},"item_1617258105262":{"attribute_name":"item_1617258105262","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"2584052","subitem_relation_type_select":"PMID"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"HiroshimaJMedSci_38_103.pdf","filesize":[{"value":"425.5 KB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2013226/files/HiroshimaJMedSci_38_103.pdf"},"version_id":"c8819b95-d493-40ce-8b25-69ef8a9087b0"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"38114"},"item_title":"Antitumor Effect of Recombinant Human Lymphotoxin on a Tumor Line of Human Malignant Glioma","item_type_id":"40003","owner":"41","path":["1730442325569"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2013226","relation_version_is_last":true,"title":["Antitumor Effect of Recombinant Human Lymphotoxin on a Tumor Line of Human Malignant Glioma"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-06-02T03:00:47.475322+00:00"}