| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Characterization of the Inactivation Process of the Sodium Channel in Frog Ventricular Cells |
|
言語 |
en |
| 作成者 |
Miyoshi, Hiroshi
Yakehiro, Masuhide
Fujiwara, Atsushi
Seyama, Issei
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Na-current |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Voltage-clamp method |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Inactivation |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Single frog ventricular cell |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
The voltage clamp experiments were conducted on single frog ventricular cells with the oil gap method for characterization of the sodium current (INa). The results obtained can be summarized as follows: 1. The falling phase of INa could be fitted by a single-exponential function when the series resistance was small (0.81-2.25 MO) and compensated. 2. Normalized steady-state inactivation (h∞) curve could be fitted by the equation h∞ = 1/(1 + exp(V-Vh)/k), where the half-inactivation voltage (Vh) was -59.8 mV and the slope factor (k) was 5.64 m V. No shift of this curve was observed throughout the experiment. 3. There was a delay of onset of inactivation development. 4. The time course for recovery of INa from inactivation exhibited a single time constant. 5. Almost all properties of the inactivation process of Na channel can be described by the original Hodgkin-Huxley's (H-H) kinetic model, except the presence of the delayed onset of inactivation. In order to incorporate this discrepancy, modification of H-H model is required, that the transition rate constant from the open state to the inactivated state may well be larger than that from the closed state to the inactivated state. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
This work was supported in part by a grant-in-aid from the Ministry of Education, Science and Culture of Japan (to I. S) and Tsuchiya Foundation (to M. Y). |
| 出版者 |
|
|
出版者 |
Hiroshima University Medical Press |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
2854825 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0018-2052 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00664312 |
| 開始ページ |
|
|
開始ページ |
139 |
| 書誌情報 |
Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences
巻 37,
号 3,
p. 139-143,
発行日 1988-09
|
| 旧ID |
38159 |
HiroshimaJMedSci_37_139.pdf (430.2 KB)
