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Study of Abnormal Formation of the Aortic Arch in Rats : By Methacrylate Casts Method and by Immunohistochemistry for Appearance and Distribution of Desmin, Myosin and Fibronectin in the Tunica Media
https://hiroshima.repo.nii.ac.jp/records/2013184
https://hiroshima.repo.nii.ac.jp/records/201318495d7941a-b79f-4567-a114-66bbf3c57e18
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HiroshimaJMedSci_37_19.pdf (3.8 MB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||
| タイトル | ||||||||
| タイトル | Study of Abnormal Formation of the Aortic Arch in Rats : By Methacrylate Casts Method and by Immunohistochemistry for Appearance and Distribution of Desmin, Myosin and Fibronectin in the Tunica Media | |||||||
| 言語 | en | |||||||
| 作成者 |
Sumida, Hiroshi
× Sumida, Hiroshi
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| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Abnormal aortic arch | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Methacrylate cast | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Desmin | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Myosin | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Fibronectin | |||||||
| 主題 | ||||||||
| 主題Scheme | NDC | |||||||
| 主題 | 490 | |||||||
| 内容記述 | ||||||||
| 内容記述 | The pathogenesis of left or right aortic arch with aberrant subclavian artery was studied by making methacrylate casts and by immunohistochemistry using antidesmin, antimyosin and antifibronectin antibodies in the rat. Maternal rats were administered a total dose of 400 mg of N,N'-bis-(dichloroacetly)-diamine (bisdiamine) on day 9-10 after conception. It was demonstrated by statistical analysis that on day 18 after conception, the absorption rate was not significantly different between the controls and the group treated with bisdiamine. Left or right aortic arch with aberrant subclavian artery was seen in about 95% of the surviving embryos from the treated group. It was shown by the casts that the period of obliteration of the dorsal aorta in the embryos from the treated group was half day earlier than that of the control embryos. In the control embryos, the left 7th intersegmental artery moved to the proximal dorsal aorta to form the left subclavian artery during development. In the embryos from the treated group, such movement of the 7th intersegmental artery was retarded. Antimyosin staining demonstrated certain cells, presumably neural crest cells, migrating to the tunica media of the dorsal aorta. After these cells reached the developing tunica media, the immunoreactivities to the antimyosin and antidesmin antibodies appeared in the tunica media. The period of appearance of the immunoreactivities in the left dorsal aorta corresponded to the period of obliteration of the right dorsal aorta in the control embryos. In the embryos from the treated group, the appearance of immunoreactivities to the antidesmin and antimyosin antibodies was half to one day later than that of the control embryos. Antifibronectin staining demonstrated that fibronectin accumulated in the developing tunica media and disappeared from the tunica media. In the embryos from the treated group, however, the disappearance of fibronectin was one day earlier than that of the control embryos. From these results, it is suggested that the obliteration of the dorsal aorta is regulated by certain cells, probably neural crest cells and that the beginning of differentiation and function of the tunica media is regulated by these cells. Bisdiamine might inhibit the action or migration of the cells. | |||||||
| 言語 | en | |||||||
| 出版者 | ||||||||
| 出版者 | Hiroshima University Medical Press | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | departmental bulletin paper | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 関連情報 | ||||||||
| 識別子タイプ | PMID | |||||||
| 関連識別子 | 3410732 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 0018-2052 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AA00664312 | |||||||
| 開始ページ | ||||||||
| 開始ページ | 19 | |||||||
| 書誌情報 |
Hiroshima Journal of Medical Sciences Hiroshima Journal of Medical Sciences 巻 37, 号 1, p. 19-36, 発行日 1988-03 |
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| 旧ID | 38140 | |||||||
