| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Newly Synthesized Compound, PABA-Ursodeoxycholic Acid, for Evaluation of Intestinal Bacteria |
|
言語 |
en |
| 作成者 |
TAKAHASHI, Makoto
MAEDA, Yorinobu
MATSUNO, Kiyoshi
TAMURA, Hiroyuki
FURUYASHIKI, Susumu
HARADA, Mitsuo
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Bile acids and salts |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Bacteria |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Intestinal diseases |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
From the standpoint of utilizing a distinctive feature of para-aminobenzoic acid (PABA) and intestinal bile acid metabolism, a conjugate of ursodeoxycholic acid with PABA (PABA-UDCA) was newly synthesized for studying whether it can be a good material or not to evaluate enteric bacteria. In incubation experiment, this compound was reasonably deconjugated by cholylglycine hydrolase resulting in the release of PABA. In animal experiment, urinary excretions of PABA were determined during six hours following oral administration of 10 mg PABA-UDCA. Control rats (n=7) excreted 140.1 ± 59.5 μ,g (mean ± SD) of PABA. By contrast, the rats (n=9) with intestinal antisepsis by antibiotic administration excreted less (18.3 ± 16. 7 μg; P < 0.001) whereas those with intestinal bacterial overgrowth by making enteric blind loop excreted more (451.1 ± 223.6 μg; P < 0.01). These observations indicate that this new compound is likely to offer a simple and rapid method for evaluation of the intestinal microorganisms. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Hiroshima University Medical Press |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
3502343 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0018-2052 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00664312 |
| 開始ページ |
|
|
開始ページ |
377 |
| 書誌情報 |
Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences
巻 36,
号 4,
p. 377-381,
発行日 1987-12
|
| 旧ID |
50004 |
HiroshimaJMedSci_36_377.pdf (650.0 KB)
