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Direct Inhibitory Effects of 17β-Estradiol on hCG-Stimulated cAMP and Testosterone Responses of Canine Testis
https://hiroshima.repo.nii.ac.jp/records/2013124
https://hiroshima.repo.nii.ac.jp/records/201312498e394dd-c15f-4cc7-9a81-789eaa5e7d87
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HiroshimaJMedSci_36_7.pdf (738.6 KB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||||
| タイトル | ||||||||||
| タイトル | Direct Inhibitory Effects of 17β-Estradiol on hCG-Stimulated cAMP and Testosterone Responses of Canine Testis | |||||||||
| 言語 | en | |||||||||
| 作成者 |
YASUKAWA, Akihiro
× YASUKAWA, Akihiro
× NIHIRA, Hiromi
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| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Estrogen | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Prostatic cancer | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Androgen | |||||||||
| 主題 | ||||||||||
| 主題Scheme | NDC | |||||||||
| 主題 | 490 | |||||||||
| 内容記述 | ||||||||||
| 内容記述 | The direct effects of 17β-estradiol (E2) on testicular function were investigated using in situ perfusion of canine testis. During perfusion of E2 (10^-8-10^-4M), we measured the concentrations of cAMP, testosterone (T), androstenedione and 5α-dihydrotestosterone (DHT) in the spermatic venous effluent after hCG (500 IU) injection into the spermatic artery. The cAMP concentration in the spermatic venous effluent was 122 ± 3. 7 (SE) pmoles/ml, increasing after hCG to a peak level of 259.1 ± 33.0 (SE) pmoles/ml at 45 min and decreasing thereafter. T increased gradually from the pretreated level of 12.2 ± 4.4 (SE) mg/ml to 90.9 ± 30.9 (SE) ng/ml at 90 min after hCG injection. Androstenedione production was also stimulated by hCG. Although the pattern of changes of DHT in the venous effluent was similar to that of T, a statistical significant increase was not observed after hCG injection. Continuous infusion with E2 at the concentrations of 10^-8-^-4 M decreased hCG-induced cAMP increase in a dose-dependent fashion. The peak level of cAMP after hCG was shown to be increasingly depleted (50 and 80%) by the increasing doses of 10^-6 and 10^-4 M of exogenous E2. The responses of T and androstenedione were also suppressed by E2 and at 10^-4 M of E2 no increase was observed, although the response of cAMP to hCG remained. These findings indicate that E2 can directly suppress the hCG-stimulated steroidogenesis and cAMP production in in situ canine testis. | |||||||||
| 言語 | en | |||||||||
| 出版者 | ||||||||||
| 出版者 | Hiroshima University School of Medicine | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 関連情報 | ||||||||||
| 識別子タイプ | PMID | |||||||||
| 関連識別子 | 3034834 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 0018-2052 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA00664312 | |||||||||
| 開始ページ | ||||||||||
| 開始ページ | 7 | |||||||||
| 書誌情報 |
Hiroshima Journal of Medical Sciences Hiroshima Journal of Medical Sciences 巻 36, 号 1, p. 7-12, 発行日 1987-03 |
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| 旧ID | 49955 | |||||||||
