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Effects of Estrogen Treatment on the Responses of cAMP and Sex Steroids to hCG by the Testes of Patients with Prostatic Cancer
https://hiroshima.repo.nii.ac.jp/records/2013123
https://hiroshima.repo.nii.ac.jp/records/20131234d9085e1-08c9-4737-8db0-be10708c368a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HiroshimaJMedSci_36_1.pdf (719.8 KB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||||
| タイトル | ||||||||||
| タイトル | Effects of Estrogen Treatment on the Responses of cAMP and Sex Steroids to hCG by the Testes of Patients with Prostatic Cancer | |||||||||
| 言語 | en | |||||||||
| 作成者 |
YASUKAWA, Akihiro
× YASUKAWA, Akihiro
× NIHIRA, Hiromi
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| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Testis | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Estrogen | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Androgen production | |||||||||
| 主題 | ||||||||||
| 主題Scheme | NDC | |||||||||
| 主題 | 490 | |||||||||
| 内容記述 | ||||||||||
| 内容記述 | The effects of diethylstilbestrol diphosphate (DESDP) on testicular steroidogenesis were investigated in patients undergoing orchiectomy for prostatic carcinoma. In non-DESDP treated patients the concentration of cAMP in the spermatic venous blood was 17.8 ± 3.1 (SE) pmoles/ml, which increased to 343.3 ± 18.6 (SE) pmoles/ml 30 min after hCG (1,000 IU) injection into the testis. T increased gradually from the pretreated level of 26.5 ± 7.2 (SE) μg/dl at 50 min. A slight increase in DHT was observed after hCG injection. Ten days' injections of DESDP significantly reduced the responses of T and DHT to hCG and 20 days' injections decreased T and DHT responses as well as cAMP response to hCG. These findings indicate that DESDP can directly suppress the hCG stimulated steroidogenesis and cAMP production in human testis in vivo. The inhibitory effects of DESDP on Leydig cell function are probably on T biosynthesis as well as on cAMP formation. | |||||||||
| 言語 | en | |||||||||
| 出版者 | ||||||||||
| 出版者 | Hiroshima University School of Medicine | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 関連情報 | ||||||||||
| 識別子タイプ | PMID | |||||||||
| 関連識別子 | 3034833 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 0018-2052 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA00664312 | |||||||||
| 開始ページ | ||||||||||
| 開始ページ | 1 | |||||||||
| 書誌情報 |
Hiroshima Journal of Medical Sciences Hiroshima Journal of Medical Sciences 巻 36, 号 1, p. 1-5, 発行日 1987-03 |
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| 旧ID | 49954 | |||||||||
