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Bioavailability, Distribution and Pharmacokinetics of Diethylstilbestrol Converted from Diethylstilbestrol Diphosphate in Patients with Prostatic Cancer
https://hiroshima.repo.nii.ac.jp/records/2013108
https://hiroshima.repo.nii.ac.jp/records/201310823bae087-f415-455f-b958-dc96384dfe6d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HiroshimaJMedSci_35_325.pdf (1.8 MB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||
| タイトル | ||||||||
| タイトル | Bioavailability, Distribution and Pharmacokinetics of Diethylstilbestrol Converted from Diethylstilbestrol Diphosphate in Patients with Prostatic Cancer | |||||||
| 言語 | en | |||||||
| 作成者 |
NAKAMURA, Koji
× NAKAMURA, Koji
|
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| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Diethylstilbestrol | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Prostatic cancer | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Dihydrotestosterone | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Androgen receptor | |||||||
| 主題 | ||||||||
| 主題Scheme | NDC | |||||||
| 主題 | 490 | |||||||
| 内容記述 | ||||||||
| 内容記述 | A method for the radioimmunoassay of diethylstilbestrol (DES) was established to evaluate the distribution of DES in patients with prostatic carcinoma receiving intravenous infusion of 500 mg of diethylstilbestrol diphosphate (DES-DP). The plasma DES concentration was markedly elevated to 4.9 μg/ml immediately after DES-DP infusion and rapidly decreased to 0.8 μg/ml at 3 hr after the DES-DP infusion. The DES concentration in the prostatic tissue was 1.6 μgig w.w. at 1 hr after infusion, and thereafter was predominantly similar to that in the plasma. The DES excretion in the urine was 23.7 mg at 0 to 3 hr after DES-DP infusion, and decreased gradually thereafter. In addition, the DES distribution in the subcellular fractions of benign hypertrophic prostates was studied following DES-DP infusion. The DES concentration in the nuclear fraction decreased with time. Furthermore, the protein specifically bound to DES was not detected in the cytosolic fraction. Therefore, the DES converted from DES-DP did not accumulate in the prostate. Subsequently, the bioavailabilities of DES were examined. The dihydrotestosterone (DHT) content of the prostatic tissue was significantly decreased at 24 hr after DES-DP infusion. However, the cytosolic androgen receptor content was insignificantly changed within 24 hr of infusion. Since the plasma luteinizing hormone (LH) level in the castrated patient with prostatic cancer was significantly lowered 3 hr after infusion, and further decreased with time, the main effect of DES was considered to be suppression of hypophyseal function. | |||||||
| 言語 | en | |||||||
| 出版者 | ||||||||
| 出版者 | Hiroshima University School of Medicine | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | departmental bulletin paper | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 関連情報 | ||||||||
| 識別子タイプ | PMID | |||||||
| 関連識別子 | 3570844 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 0018-2052 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AA00664312 | |||||||
| 開始ページ | ||||||||
| 開始ページ | 325 | |||||||
| 書誌情報 |
Hiroshima Journal of Medical Sciences Hiroshima Journal of Medical Sciences 巻 35, 号 4, p. 325-338, 発行日 1986-12 |
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| 旧ID | 49939 | |||||||
