| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Effect of Hyperprolactinemia Induced by Prolactinoma (MtT/F84) on the Accessory Sexual Organs of Male Rat |
|
言語 |
en |
| 作成者 |
NAKAMURA, Koji
NAKAMOTO, Takahisa
NIHIRA, Hiromi
FUJIMOTO, Nariaki
ITO, Akihiro
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Prolactin |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
MtT/F84 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Accessory sexual organs |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Male rats |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
A new transplantable prolactinoma, designated MtT/F84 has been serially passaged in female F344 rats. Persistently high levels of serum prolactin could be achieved in male F344 rats by MtT/F84 inoculating under the skin. This investigation deals with the effects of hyperprolactinemia upon the accessory sexual organs of male rats during puberty. The weights and the concentrations of dihydrotestosterone (DHT) in the dorsal prostate increased significantly in rats with moderate hyperprolactinemia (756 ± 179 ng/ml), but they in rats with marked hyperprolactinemia (3612 ± 1089 ng/ml) were similar t.o those of control rats. In contrast, serum testosterone levels (0.52 ± 0/17 ng/ml) in those of hyperprolactinemic rats were significantly decreased compared to that of controls (1.11± 0.13 ng/ml). These results suggested that the growth-promoting effect of prolactin on the rat prostate mediated through the action of androgen varied according to the degree of hyperprolactinemia. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Hiroshima University School of Medicine |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
3570843 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0018-2052 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00664312 |
| 開始ページ |
|
|
開始ページ |
321 |
| 書誌情報 |
Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences
巻 35,
号 4,
p. 321-324,
発行日 1986-12
|
| 旧ID |
49938 |
HiroshimaJMedSci_35_321.pdf (600.5 KB)
