Epithelial Phenotypic Expression of Human Foetal Gastrointestinal Mucosa: An Immunohistochemical Analysis

YOKOZAKI, Hiroshi

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Epithelial Phenotypic Expression of Human Foetal Gastrointestinal Mucosa: An Immunohistochemical Analysis

https://hiroshima.repo.nii.ac.jp/records/2013092

名前 / ファイル	ライセンス	アクション
HiroshimaJMedSci_35_207.pdf (16.8 MB)

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デフォルトアイテムタイプ_（フル）(1)

公開日

2023-03-18

タイトル

Epithelial Phenotypic Expression of Human Foetal Gastrointestinal Mucosa: An Immunohistochemical Analysis

言語

作成者

YOKOZAKI, Hiroshi

アクセス権

open access

アクセス権URI

http://purl.org/coar/access_right/c_abf2

主題

主題Scheme

Other

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Human foetus

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Other

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Gastrointestinal tract

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Other

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Tissue markers

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Other

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Endocrine cells

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Other

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Immunohistochemistry

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主題Scheme

NDC

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490

内容記述

Epithelial phenotypic expression in the gastrointestinal mucosa of 20 human foetuses from the 4th to 10th month of gestation was examined immunohistochemically for glycoproteins, enzymes, peptide hormones and serotonin. Goblet cells with neutral and sialomucin and brush-bordered absorptive cells were scattered in the cardia and antrum of the foetal stomach. Lysozyme was present in Paneth cells of the small intestine but not in the colon throughout the foetal period, whereas in the stomach it was seen in the surface epithelium and gastric glands in the second trimester and then became confined to pyloric and cardiac glands with the development of foetus. Secretory component was not detected in the foetal gastric mucosa but expressed in apical and basolateral cell membranes of the intestinal epithelium from the 10th gestational month. Using monoclonal antibody to carcinoembryonic antigen (CEA), only apical and lateral cell membranes of colonic epithelium from the 6th to 8th month of gestation were immunoreactive for CEA, but the stomach and small intestine had no CEA. Alpha-1-antitrypsin and alpha-1-antichymotrypsin were observed scattered in the crypts of the small intestine but were not detected in the stomach and colon. Gastrin containing cells were less in number than somatostatin containing cells in the stomach but dramatically increased from the 8th month of gestation. Serotonin containing cells showed the closed type in the stomach, the open type in the small intestine and both in the colon of the foetus. Glicentin containing cells were present in the fundic mucosa from the 5th to the last gestational month. Calcitonin was not detected in the foetal gut mucosa. These results suggest that the expression of these tissue markers in intestinal metaplasia and adenocarcinoma of the stomach cannot be explained merely by the reversion to the foetal gastric phenotype.

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内容記述

内容記述タイプ

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内容記述

Some sections of this manuscript were presented at the 43rd Annual Meeting of the Japanese Cancer Association, October 3-5, 1984. Fukuoka, Japan and at the 75th Annual Meeting of the Japanese Pathological Society, April 8-10, 1986, Sendai, Japan.

出版者

Hiroshima University School of Medicine

言語

eng

資源タイプ

資源タイプ識別子

http://purl.org/coar/resource_type/c_6501

資源タイプ

departmental bulletin paper

出版タイプ

VoR

出版タイプResource

http://purl.org/coar/version/c_970fb48d4fbd8a85

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2025-02-23 06:23:19.576532

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Epithelial Phenotypic Expression of Human Foetal Gastrointestinal Mucosa: An Immunohistochemical Analysis

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