{"created":"2025-02-23T06:23:07.746770+00:00","id":2013086,"links":{},"metadata":{"_buckets":{"deposit":"91af9160-9821-49ab-9ed4-b1be1759aa9e"},"_deposit":{"created_by":41,"id":"2013086","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2013086"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02013086","sets":["1727147343679:1730442224523:1730442334132"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Familial Aggregation of Duodenal Ulcer and an Autosomal Dominant Inheritance of Hyperpepsinogenemia I","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"SUMII, Koji","creatorNameLang":"en"}],"familyNames":[{"familyName":"SUMII","familyNameLang":"en"}],"givenNames":[{"givenName":"Koji","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"UEMURA, Naomi","creatorNameLang":"en"}],"familyNames":[{"familyName":"UEMURA","familyNameLang":"en"}],"givenNames":[{"givenName":"Naomi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"INBE, Akira","creatorNameLang":"en"}],"familyNames":[{"familyName":"INBE","familyNameLang":"en"}],"givenNames":[{"givenName":"Akira","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"HARUMA, Ken","creatorNameLang":"en"}],"familyNames":[{"familyName":"HARUMA","familyNameLang":"en"}],"givenNames":[{"givenName":"Ken","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"INABA, Yoshiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"INABA","familyNameLang":"en"}],"givenNames":[{"givenName":"Yoshiro","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"TARI, Akira","creatorNameLang":"en"}],"familyNames":[{"familyName":"TARI","familyNameLang":"en"}],"givenNames":[{"givenName":"Akira","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"YOSHIHARA, Masaharu","creatorNameLang":"en"}],"familyNames":[{"familyName":"YOSHIHARA","familyNameLang":"en"}],"givenNames":[{"givenName":"Masaharu","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"SEKITOH, Masaki","creatorNameLang":"en"}],"familyNames":[{"familyName":"SEKITOH","familyNameLang":"en"}],"givenNames":[{"givenName":"Masaki","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"TOKUTOMI, Tadashi","creatorNameLang":"en"}],"familyNames":[{"familyName":"TOKUTOMI","familyNameLang":"en"}],"givenNames":[{"givenName":"Tadashi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"KAJIYAMA, Goro","creatorNameLang":"en"}],"familyNames":[{"familyName":"KAJIYAMA","familyNameLang":"en"}],"givenNames":[{"givenName":"Goro","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"MIYOSHI, Akima","creatorNameLang":"en"}],"familyNames":[{"familyName":"MIYOSHI","familyNameLang":"en"}],"givenNames":[{"givenName":"Akima","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Duodenal ulcer","subitem_subject_scheme":"Other"},{"subitem_subject":"Hyperpepsinogenemia I","subitem_subject_scheme":"Other"},{"subitem_subject":"Autosomal dominant inheritance","subitem_subject_scheme":"Other"},{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"To clarify genetic factors involved in the familial aggregation of duodenal ulcer, serum pepsinogen I levels were determined by radioimmunoassay in patients with duodenal ulcer and their affected and unaffected relatives.  There existed relationship between an elevated pepsinogen I level and susceptability of duodenal ulcer, and the familial aggregation of duodenal ulcer. The segregation analysis revealed that hyperpepsinogenemia I was inherited as an autosomal dominant inheritance, and in some families this trait was responsible for familial aggregation of duodenal ulcer. But in other families normopepsinogenemic I duodenal ulcer has segregated and association to pathophysiological factors of this trait was obscure. These data provide evidence that genetic factors play a role in pathogenesis of duodenal ulcer, and that hyperpepsinogenemia I is one of genetic markers of this disease.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Hiroshima University School of Medicine"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0018-2052","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00664312","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"開始ページ","attribute_value_mlt":[{"subitem_start_page":"171"}]},"item_1617187056579":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1986-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"175","bibliographicPageStart":"171","bibliographicVolumeNumber":"35","bibliographic_titles":[{"bibliographic_title":"Hiroshima Journal of Medical Sciences"},{"bibliographic_title":"Hiroshima Journal of Medical Sciences"}]}]},"item_1617258105262":{"attribute_name":"item_1617258105262","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"3771276","subitem_relation_type_select":"PMID"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"HiroshimaJMedSci_35_171.pdf","filesize":[{"value":"574.4 KB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2013086/files/HiroshimaJMedSci_35_171.pdf"},"version_id":"d427060a-c4b4-4b54-adfe-e44ba79516e6"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"49917"},"item_title":"Familial Aggregation of Duodenal Ulcer and an Autosomal Dominant Inheritance of Hyperpepsinogenemia I","item_type_id":"40003","owner":"41","path":["1730442334132"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2013086","relation_version_is_last":true,"title":["Familial Aggregation of Duodenal Ulcer and an Autosomal Dominant Inheritance of Hyperpepsinogenemia I"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-06-02T02:56:34.679240+00:00"}