| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Immunohistochemical Studies of Experimental Diabetic Neuropathy |
|
言語 |
en |
| 作成者 |
KITO, Shozo
KISHIDA, Takenobu
MATSUBAYASHI, Hiroaki
MIYOSHI, Rie
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Streptozotocin-diabetic rats |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Ischiadic nerve |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Immunohistochemistry |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Aldose reductase inhibitor |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Accumulations of substance P, somatostatin, vasoactive intestinal polypeptide (VIP) and dopamine-/3-hydroxylase (DBH) after ligation of the ischiadic nerve of streptozotocininduced diabetic rats were observed by an immunohistochemical technique and the results were examined both qualitatively and quantitatively. Besides, effects of administration of an aldose reductase inhibitor (ONO 2235), a key enzyme for polyol synthesis, on these accumulation patterns were studied. Immunofluorescent positiveness of these biological active substances was intensely observed along the axon in nerves of control animals. In the ischiadic nerves of diabetic rats, it was weakly observed in irregular shapes. On the other hand, in the ischiadic nerve of the diabetic rat treated with the aldose reductase inhibitor, substance P-, DBH- and VIP- immunoreactive positiveness was recovered in both distribution pattern and accumulation length. Our findings show that there are abnormalities of the axonal flow of the peripheral nerve in diabetic animals. These results also suggest that polyol pathway activity may contribute to the pathogenesis of diabetic neuropathy and ONO-2235 may be useful in preventing diabetic complications. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Hiroshima University School of Medicine |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
3533860 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0018-2052 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00664312 |
| 開始ページ |
|
|
開始ページ |
109 |
| 書誌情報 |
Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences
巻 35,
号 2,
p. 109-115,
発行日 1986-06
|
| 旧ID |
49909 |
HiroshimaJMedSci_35_109.pdf (4.9 MB)
