WEKO3
アイテム
Concentration-Dependence of Halothane Metabolism in Rabbits
https://hiroshima.repo.nii.ac.jp/records/2013062
https://hiroshima.repo.nii.ac.jp/records/201306273f9422d-95eb-4923-ab9f-33f5061fa27c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HiroshimaJMedSci_35_15.pdf (857.8 KB)
|
| アイテムタイプ | デフォルトアイテムタイプ_（フル）(1) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Concentration-Dependence of Halothane Metabolism in Rabbits | |||||||||||
| 言語 | en | |||||||||||
| 作成者 |
OKIDA, Motoichi
× OKIDA, Motoichi
× KIKUCHI, Hirosato
× FUJII, Kohyu
|
|||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Biotransformation | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Concentration-dependence | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Halothane | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | NDC | |||||||||||
| 主題 | 490 | |||||||||||
| 内容記述 | ||||||||||||
| 内容記述 | Effect of end-expiratory halothane concentration on its aerobic and anaerobic metabolism was studied in 20 male rabbits. Biliary excretion of trifluoroacetic acid (TF AA), an aerobic metabolite of halothane, and the pulmonary excretion of CF2CHCl (CDFF) and CF3CH2Cl (CTFE), anaerobic metabolites of halothane, were measured simultaneously during 5 hr of inhalation at various concentrations of halothane (0.02-1.5%). The total amount of biliary TF AA excreted for 5 hr remained unchanged (38.4μmol- 44.lμmol) at each concentration except 0.02%. However, the total amount of CDFE and CTFE excreted for 5 hr increased in a concentration-dependent manner up to 0.5% end-expiratory halothane, and remained unchanged (47.2μmol-64.7μmol) at more than 0.5%. Total biliary excretion of TF AA reached its maximum at a 0.05%. These results suggest that the primary route of halothane metabolism at a subanesthetic concentration is the aerobic pathway which produces TF AA. However, at anesthetic concentration exceeding 0.5%, the anaerobic route which produces volatile CDFE and CTFE plays a role also as an aerobic route. | |||||||||||
| 言語 | en | |||||||||||
| 内容記述 | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | This study was supported in part by Science Research Grants from the Ministry of Education, Science and Culture of Japan | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | Hiroshima University School of Medicine | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| 関連情報 | ||||||||||||
| 識別子タイプ | PMID | |||||||||||
| 関連識別子 | 3744878 | |||||||||||
| 収録物識別子 | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 0018-2052 | |||||||||||
| 収録物識別子 | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AA00664312 | |||||||||||
| 開始ページ | ||||||||||||
| 開始ページ | 15 | |||||||||||
| 書誌情報 |
Hiroshima Journal of Medical Sciences Hiroshima Journal of Medical Sciences 巻 35, 号 1, p. 15-20, 発行日 1986-03 |
|||||||||||
| 旧ID | 49893 | |||||||||||
