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Clinical Studies on Reversibility of Pulmonary Airway Dysfunctions in Asymptomatic Smokers: Role of Nervous Mechanism in Small Airway Disease
https://hiroshima.repo.nii.ac.jp/records/2013052
https://hiroshima.repo.nii.ac.jp/records/2013052e5c62f66-ac76-48ce-934c-3ff07041e075
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HiroshimaJMedSci_34_399.pdf (2.4 MB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||
| タイトル | ||||||||
| タイトル | Clinical Studies on Reversibility of Pulmonary Airway Dysfunctions in Asymptomatic Smokers: Role of Nervous Mechanism in Small Airway Disease | |||||||
| 言語 | en | |||||||
| 作成者 |
Md. Masudur Rahman
× Md. Masudur Rahman
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| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Nonsmoker and smoker | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Pulmonary function tests | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Volume of isoflow | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Reversibility of airway dysfunctions | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Cholinergic nerve | |||||||
| 主題 | ||||||||
| 主題Scheme | NDC | |||||||
| 主題 | 490 | |||||||
| 内容記述 | ||||||||
| 内容記述 | Pulmonary function tests were performed on twenty eight males, among whom eight were healthy nonsmokers and twenty were asymptomatic smokers. Pulmonary function tests such as spirometry, respiratory impedance (Z3Hz), single breath nitrogen washout (SBN2) and volume of isoflow (VisoV) were done before and after inhalation of orciprenaline sulphate and atropine sulphate in all nonsmokers and smokers. Subdivisions of lung volume, diffusing capacity (DLco) and arterial blood gas analysis were conducted only before inhalation of drugs. Acute effects were studied after smoking a cigarette and effects of orciprenaline inhalation after smoking were also observed. Furthermore, effects of smoking on prior inhalation of orciprenaline, atropine or lidocaine were evaluated. The results obtained were as follows: 1) There were no differences in the results of routine pulmonary function tests, between nonsmokers and smokers except Z3Hz, which was significantly higher in smokers (p<0.01) and there was a tendency to decrease in flow especially at low lung volumes in smokers. Smokers could be well differentiated from nonsmokers by VisoV/FVC (p<0.001) and the difference in distribution of ventilation was greater (p<0.05). 2) In nonsmokers, Z3Hz decreased and V50 increased significantly after inhalation of orciprenaline and atropine. FEV1.o increased significantly with atropine inhalation only. There were no changes in VisoV/FVC with inhalation of orciprenaline or atropine. In smokers, Z3Hz and VisoV/FVC decreased significantly after inhalation of orciprenaline or atropine (p<0.001). FEV1.o and flow rates improved significantly with both drugs. 3) After smoking a cigarette, Z3Hz and VisoV/FVC significantly increased (p < 0.01), but inhalation of orciprenaline or atropine prior to smoking significantly inhibited the acute effects of smoking and lidocaine completely inhibited the acute effects of smoking. These results indicate that several parameters such as Z3Hz, flow at low lung volume, VisoV/FVC could detect the airway dysfunctions in asymptomatic cigarette smokers. These airway dysfunctions might be due to increased vagal tone, leading to narrowing of the airways and these airway dysfunctions were reversible by bronchodilator drugs. | |||||||
| 言語 | en | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | This study was performed in the Second Department of Internal Medicine, Hiroshima University School of Medicine, under a scholarship granted by The Ministry of Education, Science and Culture (Monbusho), The Government of Japan. | |||||||
| 出版者 | ||||||||
| 出版者 | Hiroshima University School of Medicine | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | departmental bulletin paper | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 関連情報 | ||||||||
| 識別子タイプ | PMID | |||||||
| 関連識別子 | 3830997 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 0018-2052 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AA00664312 | |||||||
| 開始ページ | ||||||||
| 開始ページ | 399 | |||||||
| 書誌情報 |
Hiroshima Journal of Medical Sciences Hiroshima Journal of Medical Sciences 巻 34, 号 4, p. 399-418, 発行日 1985-12 |
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| 旧ID | 49883 | |||||||
