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Effects of Feeding Regimen on 1,2-Dimethylhydrazine-Induced Intestinal Carcinogenesis in Rats
https://hiroshima.repo.nii.ac.jp/records/2013050
https://hiroshima.repo.nii.ac.jp/records/2013050b5e199e9-e6c8-4c52-adc4-838f535cdef9
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HiroshimaJMedSci_34_387.pdf (923.8 KB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||
| タイトル | ||||||||
| タイトル | Effects of Feeding Regimen on 1,2-Dimethylhydrazine-Induced Intestinal Carcinogenesis in Rats | |||||||
| 言語 | en | |||||||
| 作成者 |
SUMIYOSHI, Hiromichi
× SUMIYOSHI, Hiromichi
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| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | 1,2-dimethylhydrazine | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Feeding regimen | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Intestinal carcinogenesis | |||||||
| 主題 | ||||||||
| 主題Scheme | NDC | |||||||
| 主題 | 490 | |||||||
| 内容記述 | ||||||||
| 内容記述 | The effects of feeding regimens on 1,2-dimethylhydrazine (DMH)-induced intestinal carcinogenesis were investigated in male Wistar strain rats. The development of intestinal tumors in rats fed the semipurified powdered diet (SPD) required a longer latent time than that of rats fed the basal pelleted diet (BPD) and the incidence of the tumors, especially adenomas and well differentiated adenocarcinomas, also significantly decreased in the SPD group. However, the incidence of liver cell carcinomas was higher in the SPD group than in the BPD group. Total bile acid levels in bile were not affected by the diet, but bile acid secretion per hour in the SPD group significantly decreased due to the decrease of bile secretion. Moreover, in the SPD group the colonic epithelial cell proliferation was depressed and the cell cycle time was prolonged when compared to that in the BPD group. These changes might result in a significant decreased incidence of adenomas and well differentiated adnocarcinomas in the SPD group. These results indicate that feeding regimens play an important role in the proliferation of intestinal epithelial cells and the bile secretion and that they influence not only the development of intestinal tumors but also the organospecific carcinogenesis induced by DMH. | |||||||
| 言語 | en | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | Some sections of this manuscript were presented at the 43rd Annual Meeting of the Japanese Cancer Association, October 3-5, 1984, Fukuoka, Japan. | |||||||
| 出版者 | ||||||||
| 出版者 | Hiroshima University School of Medicine | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | departmental bulletin paper | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 関連情報 | ||||||||
| 識別子タイプ | PMID | |||||||
| 関連識別子 | 3830995 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 0018-2052 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AA00664312 | |||||||
| 開始ページ | ||||||||
| 開始ページ | 387 | |||||||
| 書誌情報 |
Hiroshima Journal of Medical Sciences Hiroshima Journal of Medical Sciences 巻 34, 号 4, p. 387-393, 発行日 1985-12 |
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| 旧ID | 49881 | |||||||
