WEKO3
アイテム
Effects of Vitamin E Deficiency on 1,2-Dimethylhydrazine-Induced Intestinal Carcinogenesis in Rats
https://hiroshima.repo.nii.ac.jp/records/2013046
https://hiroshima.repo.nii.ac.jp/records/2013046cbb59e70-f60c-43de-9842-d93a91feca09
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HiroshimaJMedSci_34_363.pdf (925.6 KB)
|
| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||
| タイトル | ||||||||
| タイトル | Effects of Vitamin E Deficiency on 1,2-Dimethylhydrazine-Induced Intestinal Carcinogenesis in Rats | |||||||
| 言語 | en | |||||||
| 作成者 |
SUMIYOSHI, Hiromichi
× SUMIYOSHI, Hiromichi
|
|||||||
| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | 1,2-dimethylhydrazine | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Vitamin E deficiency | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Intestinal carcinogenesis | |||||||
| 主題 | ||||||||
| 主題Scheme | NDC | |||||||
| 主題 | 490 | |||||||
| 内容記述 | ||||||||
| 内容記述 | The effects of vitamin E deficiency on intestinal carcinogenesis and intestinal epithelial cell kinetics were investigated in male Wistar strain rats treated with 1,2-dimethylhydrazine (DMH) dihydrochloride. In the time course study of intestinal tumors induced by DMH (20 mg/kg, 20 weekly s.c. injections), at the early stage when no intestinal tumor was observed in control rats, tumor-bearing rats were detected in the vitamin E deficient group. Moreover, in rats treated with DMH (20 mg/kg, 3 weekly s.c. injections) after vitamin E deficient status, the incidence of rats with intestinal tumors was significantly higher in the vitamin E deficient group (58.3 %) than in the sufficient group (8.3 %) at 15 weeks after DMH treatment (p<0.05). However, after 45 weeks the incidence of tumors was the same in the both groups. In the cell kinetics study at 15 weeks after DMH treatment, DNA synthsis in the intestinal mucosa increased significantly in the vitamin E deficient group compared to that of the sufficient group. Nevertheless, the life span of intestinal epithelium was shorter in vitamin E deficient rats than in sufficient rats. These results suggest that vitamin E deficiency promotes the initiation in colon carcinogenesis induced by DMH but inhibits the growth of the tumor. | |||||||
| 言語 | en | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | Some sections of this manuscript were presented at the 73rd Annual Congress of the Japanese Pathological Society, April 3-5, 1984, Tokyo and the third International Congress on Cell Biology, August 26-31, 1984, Tokyo, Japan. | |||||||
| 出版者 | ||||||||
| 出版者 | Hiroshima University School of Medicine | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | departmental bulletin paper | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 関連情報 | ||||||||
| 識別子タイプ | PMID | |||||||
| 関連識別子 | 4066404 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 0018-2052 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AA00664312 | |||||||
| 開始ページ | ||||||||
| 開始ページ | 363 | |||||||
| 書誌情報 |
Hiroshima Journal of Medical Sciences Hiroshima Journal of Medical Sciences 巻 34, 号 3, p. 363-369, 発行日 1985-09 |
|||||||
| 旧ID | 49877 | |||||||
