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Some Statistical Issues Pertaining to in Vitro Drug Testing with Human Tumor Colony Forming Assays
https://hiroshima.repo.nii.ac.jp/records/2012999
https://hiroshima.repo.nii.ac.jp/records/201299981e3cab2-96ed-40d5-8b52-6b30a24b23a9
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HiroshimaJMedSci_34_31.pdf (992.9 KB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||
| タイトル | ||||||||
| タイトル | Some Statistical Issues Pertaining to in Vitro Drug Testing with Human Tumor Colony Forming Assays | |||||||
| 言語 | en | |||||||
| 作成者 |
KOZIOL, James A.
× KOZIOL, James A.
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| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | In vitro drug testing | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Salmon assay | |||||||
| 主題 | ||||||||
| 主題Scheme | NDC | |||||||
| 主題 | 490 | |||||||
| 内容記述 | ||||||||
| 内容記述 | One should proceed with prudence in the interpretation and application of in vitro drug tests. Among the statistical considerations that should be borne in mind are the following: 1. Reproducibility of in vitro assays should be adequately addressed. 2. Experimental designs for in vitro assays need further development, and should take account of the underlying biology of in vitro cell growth, and drug pharmacology. 3. Sensitivity, specificity, and predictive values are commonly used summary indices of in vitro - in vivo associations, but arise from dichotomization of laboratory and clinical data with loss of information. Objective criteria are needed for in vitro outcomes; and, in vivo outcomes should be chosen to reflect survival advantage. 4. Multivariate statistical techniques that assess whether in vitro assays provide additional information for predicting clinical outcome with other available prognostic criteria can be useful. However, these analyses presuppose adherence to statistical criteria for experimental design (including adequate sample sizes) and require prospective evaluation. Extrapolation of results from one clinical setting to another should be done with caution. | |||||||
| 言語 | en | |||||||
| 出版者 | ||||||||
| 出版者 | Hiroshima University School of Medicine | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | departmental bulletin paper | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 関連情報 | ||||||||
| 識別子タイプ | PMID | |||||||
| 関連識別子 | 4019238 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 0018-2052 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AA00664312 | |||||||
| 開始ページ | ||||||||
| 開始ページ | 31 | |||||||
| 書誌情報 |
Hiroshima Journal of Medical Sciences Hiroshima Journal of Medical Sciences 巻 34, 号 1, p. 31-37, 発行日 1985-03 |
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| 旧ID | 49830 | |||||||
