{"created":"2025-02-23T06:19:46.373683+00:00","id":2012968,"links":{},"metadata":{"_buckets":{"deposit":"ae3f042a-80f4-4d68-9a99-9143fad3ce5e"},"_deposit":{"created_by":41,"id":"2012968","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2012968"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02012968","sets":["1727147343679:1730442224523:1730442338714"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Metabolism of an Antiallergic Agent, Azelastine (4-(p-Chlorobenzyl)-2-[N-Methylperhydroazepinyl-(4)]- 1-(2H)-Phthalazinone Hydrochloride) in Rats and Guinea Pigs","subitem_title_language":"en"},{"subitem_title":"ラットおよびモルモットにおける抗アレルギー剤 azelastine の代謝","subitem_title_language":"ja"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tatsumi, Kiyoshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Tatsumi","familyNameLang":"en"}],"givenNames":[{"givenName":"Kiyoshi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yamada, Hideyuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Yamada","familyNameLang":"en"}],"givenNames":[{"givenName":"Hideyuki","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yoshimura, Hidetoshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Yoshimura","familyNameLang":"en"}],"givenNames":[{"givenName":"Hidetoshi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nishizawa, Yukio","creatorNameLang":"en"}],"familyNames":[{"familyName":"Nishizawa","familyNameLang":"en"}],"givenNames":[{"givenName":"Yukio","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sakai, Misao","creatorNameLang":"en"}],"familyNames":[{"familyName":"Sakai","familyNameLang":"en"}],"givenNames":[{"givenName":"Misao","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Mizuo, Hitoshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Mizuo","familyNameLang":"en"}],"givenNames":[{"givenName":"Hitoshi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yamato, Chiyuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Yamato","familyNameLang":"en"}],"givenNames":[{"givenName":"Chiyuki","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Metabolism","subitem_subject_scheme":"Other"},{"subitem_subject":"Azelastine","subitem_subject_scheme":"Other"},{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"The in vivo metabolism of an antiallergic agent, azelastine, (4-(p-chlorobenzyl)-2-[N-methylperhydroazepinyl-(4)]-1-(2H)-phthalazinone hydrochloride) was examined following oral administration to rats and guinea pigs. As a result, it was found that the drug was metabolized to 4-(p-chlorobenzyl)-2-[N-methyl-7-oxo-perhydroazepinyl-(4)]-1-(2H)-phthalazinone, 6-hydroxy-4-(p-chlorobenzyl)-2-[N-methylperhydroazepinyl-(4)]-1-(2H)-phthalazinone (6-hydroxyazelastine), 7-hydroxy-4-(p-chlorobenzyl)-2-[N-methyl -perhydroazepinyl-(4)]-1-(2H)-phthalazinone and 4-(p-chlorobenzyl)-2-[perhydroazepinyl-(4)]-1-(2H)-phthalazinone (desmethylazelastine) in these animal bodies. A part of the hydroxy derivatives of the drug was excreted into urine as their glucuronides. In addition, the incubation of azelastine with rat liver microsomes resulted in the formation of 6-hydroxyazelastine and desmethylazelastine in the presence of an NADPH-generating system.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Hiroshima University School of Medicine"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0018-2052","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00664312","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"開始ページ","attribute_value_mlt":[{"subitem_start_page":"669"}]},"item_1617187056579":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1984-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"678","bibliographicPageStart":"669","bibliographicVolumeNumber":"33","bibliographic_titles":[{"bibliographic_title":"Hiroshima Journal of Medical Sciences"},{"bibliographic_title":"Hiroshima Journal of Medical Sciences"}]}]},"item_1617258105262":{"attribute_name":"item_1617258105262","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"6152559","subitem_relation_type_select":"PMID"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"HiroshimaJMedSci_33_669.pdf","filesize":[{"value":"584.4 KB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2012968/files/HiroshimaJMedSci_33_669.pdf"},"version_id":"53a600ba-6d8a-4077-93ed-54a53cca2665"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"38266"},"item_title":"Metabolism of an Antiallergic Agent, Azelastine (4-(p-Chlorobenzyl)-2-[N-Methylperhydroazepinyl-(4)]- 1-(2H)-Phthalazinone Hydrochloride) in Rats and Guinea Pigs","item_type_id":"40003","owner":"41","path":["1730442338714"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2012968","relation_version_is_last":true,"title":["Metabolism of an Antiallergic Agent, Azelastine (4-(p-Chlorobenzyl)-2-[N-Methylperhydroazepinyl-(4)]- 1-(2H)-Phthalazinone Hydrochloride) in Rats and Guinea Pigs"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-06-02T02:53:46.673124+00:00"}