| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Characterization of the Lag Phase of Insulin Action on Glucose Transport in Rat Isolated Adipocytes |
|
言語 |
en |
| タイトル |
|
|
タイトル |
ラット遊離脂肪細胞の糖輸送におけるインスリン作用発現時間の遅延に関する検討 |
|
言語 |
ja |
| 作成者 |
Kubo, Keiji
Ogawa, Junichiro
Kobuke, Akiko
Takami, Kyoko
Tango, Yunus
Egusa, Genshi
Kawase, Tohru
Yamamoto, Shinichi
Hara, Hitoshi
Nishimoto, Yukio
Ishibashi, Fukashi
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Fasting |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Insulin analogues |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Low pH |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Low temperature |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Insulin action on glucose transport in isolated rat adipocytes was assessed using the method originally reported by Whitesell et al. Insulin increased the Vmax of glucose transport without affecting the Km. So far as concentration dependence of insulin action it had pH and temperature dependency, and analogue specificity quite similar to previous reports. The lag phase (time necessary for full exhibition) of insulin action has never been paid much attention, since suitable system for studying it has never been developed, and since only recently post receptor processes of insulin actions were interested in detecting insulin resistance. Insulin action on glucose transport reached the maximum in 3 min with half maximal response at 1.8 min. Lowering the pH or temperature of incubation medium prolonged the period for half maximal response. On the other hand, various insulin analogues required comparable period with insulin for full exhibition of their actions. When isolated adipocytes were obtained from rats fasted for 48 hours, the period for half maximal response was markedly prolonged (12 min). It might be suggested that in some insulin resistant conditions such as diabetic ketoacidosis and hunger, the delayed initiation of insulin action may be involved. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Hiroshima University School of Medicine |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
6384142 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0018-2052 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00664312 |
| 開始ページ |
|
|
開始ページ |
65 |
| 書誌情報 |
Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences
巻 33,
号 1,
p. 65-71,
発行日 1984-03
|
| 旧ID |
38175 |
HiroshimaJMedSci_33_65.pdf (480.8 KB)
