| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Experimental Studies on Developmental Mechanism of Histamine Induced Ulcers and Ulcer Inhibitory Effects of Histamine Receptor Antagonists |
|
言語 |
en |
| タイトル |
|
|
タイトル |
ヒスタミン潰瘍発生機序ならびにヒスタミン受容体拮抗剤の潰瘍抑制効果 |
|
言語 |
ja |
| 作成者 |
Kodama, Motomu
Ogawa, Yoshiteru
Ito, Nobuaki
Takeuchi, Hitoshi
Seikoh, Rokuro
Tanaka, Tsuneo
Harada, Mitsuo
Kodama, Osamu
Ezaki, Haruo
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Histamine induced ulcer |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Histamine receptor antagonists |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Study was made of the developmental mechanism of histamine induced ulcers and inhibitory effects of receptor antagonists from the view point of gastric acidity and microvasculature of the gastric mucosa, and the following results were obtained. 1. In histamine induced ulcers, hypersecretion of gastric acid caused by histamine is not the primary developmental mechanism of the lesion. The main cause is considered to be disturbance of microcirculation in the gastric mucosa attributable to the effects of histamine on the microvasculature of the mucosa. 2. Of the histamine receptor antagonists, diphenhydramine, an Hi-antagonist, was unable to inhibit hypersecretion of gastric acid and disturbance of microcirculation of the gastric mucosa caused by histamine, and thus could not suppress the development of histamine induced ulcers, but cimetidine, an H2-antagonist, inhibited not only hypersecretion of gastric acid, but also prevent disturbance of microcirculation in the mucosa, and consequently suppressed histamine induced ulcers. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Hiroshima University School of Medicine |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
6643109 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0018-2052 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00664312 |
| 開始ページ |
|
|
開始ページ |
311 |
| 書誌情報 |
Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences
巻 32,
号 3,
p. 311-318,
発行日 1983-09
|
| 旧ID |
38326 |
HiroshimaJMedSci_32_311.pdf (1.1 MB)
