| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Role of Regulatory T Cells on the Age-Related Increase in Mitogen-Induced IgG Production in Vitro by Human Lymphocytes |
|
言語 |
en |
| タイトル |
|
|
タイトル |
加令によるヒトリンパ球の mitogen による lgG 産生の増強 : 特に T 細胞の効果について |
|
言語 |
ja |
| 作成者 |
Yamakido, Michio
Takaishi, Masatoshi
Onari, Kiyoshi
Akiyama, Mitoshi
Inamizu, Tsutomu
Ishioka, Shinichi
Nishimoto, Yukio
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Aging |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Human lymphocytes |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
IgG production |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
T cells |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
When in vitro IgG production by mitogen-stimulated peripheral lymphocytes from healthy aged (70-93 year old) and young (20-29 year old) subjects was compared, it was found that the level of IgG production was elevated in the aged subjects. Co-culture studies were performed to determine whether the increase was clue to changes in T or non-T cells. IgG production was significantly higher when reference non-T cells from normal young adults were mixed with T cells from aged subjects than with T cells from young adults. In contrast, no significant difference in IgG production was observed when reference T cells from normal young adults were mixed with non-T cells from either young or aged subjects. The suppressor activity of Tγ cells and helper activity of non-Tγ T cells of young and aged subjects were then determined. The results revealed that the suppressor activity of Tγ cells of aged individuals was significantly lower than that of young adults, but the helper activity of non-Tγ T cells of young and aged subjects was comparable. These results indicate that the increase in production of IgG by the peripheral lymphocytes of aged individuals is due in part to changes in the T cells which are related to a decrease in suppressor activity of Tγ cells. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Hiroshima University School of Medicine |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
6225753 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0018-2052 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00664312 |
| 開始ページ |
|
|
開始ページ |
199 |
| 書誌情報 |
Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences
巻 32,
号 2,
p. 199-206,
発行日 1983-06
|
| 旧ID |
38340 |
HiroshimaJMedSci_32_199.pdf (622.9 KB)
