| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Sympathetic Nerve and Hormonal Responses to a Single Dose of Nifedipine in Patients with Essential Hypertension and Normal Subjects : Comparison Among Renin-Subgroups |
|
言語 |
en |
| タイトル |
|
|
タイトル |
本態性高血圧症患者および正常血圧者の Nifedipine 1回経口投与に対する交感神経ならびに内分泌応答のレニン群間比較 |
|
言語 |
ja |
| 作成者 |
Oemar, Hamed
Kubo, Shigeko
Masaoka, Satoko
Kanazawa, Ikuo
Yuasa, Akira
Tsuchioka, Yukiko
Matsuura, Hideo
Kurogane, Hiroyuki
Kajiyama, Goro
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Essential hypertension |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Nifedipine |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Catecholamines |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Renin-angiotensinaldosterone system |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Renin subgroup |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Behaviors of sympathetic and renin-angiotensin-aldosterone systems to an acute sublingual administration of nifedipine (10 mg) were studied in essential hypertensive (EHT) and normotensive (NT) groups. Basal values of plasma norepinephrine (NE) and plasma renin activity (PRA) were not consistent with mean blood pressure (BP), indicating no important role of NE and PRA values for determining BP level. Nifedipine reduced BP, and increased NE and PRA in both groups. Simultaneously, nifedipine produced a significant decrease of plasma aldosterone concentration (PAC) and plasma cortisol. High-renin EHT subgroup showed greater responses of BP, NE and PRA than normal- or low-renin subgroup but not in NT group. In high-, normal- and low-renin subgroups of both groups, the correlations between mean BP and △mean BP (r= -0.85, p<0.001; r= -0.89, p<0.001 and r= -0.77, p<0.001, respectively), △mean BP and △NE (r= -0.76, p<0.01; r= -0.71, p<0.05 and r= -0.57, NS, respectively) and △mean BP and △PRA (r= -0.87, p<0.001; r=0.59, NS and r= -0.05, NS, respectively) were observed. A significant relationship between basal PRA and △PRA was demonstrated in EHT group (r=0.77, p<0.001) but not in NT group (r=0.37, NS). These data indicate the presence of high vascular tone in high-renin EHT subgroup which is probably produced by an increased vascular responsiveness to sympathetic and/or to angiotensin II or by some other factors. It is suspected that juxtaglomerular cell response to vasodilator may be altered in patients with low-renin essential hypertension. The present study also suggests that nifedipine blocked aldosterone and cortisol secretion through Ca++ influx inhibition into the adrenal cortex. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Hiroshima University School of Medicine |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
6352568 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0018-2052 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00664312 |
| 開始ページ |
|
|
開始ページ |
187 |
| 書誌情報 |
Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences
巻 32,
号 2,
p. 187-197,
発行日 1983-06
|
| 旧ID |
38339 |
HiroshimaJMedSci_32_187.pdf (841.1 KB)
