{"created":"2025-02-23T06:16:33.340830+00:00","id":2012855,"links":{},"metadata":{"_buckets":{"deposit":"3eba408c-a4c1-494c-bb44-a89d2842bc42"},"_deposit":{"created_by":41,"id":"2012855","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2012855"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02012855","sets":["1727147343679:1730442224523:1730442343955"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Effects of Bacterial Immunopotentiators, LC 9018 and OK-432, on the Resistance Against Mycobacterium intracellulare Infection in Mice","subitem_title_language":"en"},{"subitem_title":"細菌性免疫促進剤 LC9018 並びに OK-432 のマウスでの実験的 Mycobacterium intracellulare 感染症に対する宿主抵抗性に及ぼす効果","subitem_title_language":"ja"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Saito, Hajime","creatorNameLang":"en"}],"familyNames":[{"familyName":"Saito","familyNameLang":"en"}],"givenNames":[{"givenName":"Hajime","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nagashima, Kiyofumi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Nagashima","familyNameLang":"en"}],"givenNames":[{"givenName":"Kiyofumi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tomioka, Haruaki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Tomioka","familyNameLang":"en"}],"givenNames":[{"givenName":"Haruaki","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Bacterial immunopotentiator","subitem_subject_scheme":"Other"},{"subitem_subject":"Mycobacterium intracellulare","subitem_subject_scheme":"Other"},{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Bacterial immunopoteniators, Lactobacillus casei YIT 9018 (LC 9018) and penicillin G-treated Streptococcus pyogenes (OK-432), were examined for their effects on the host resistance against Mycobacterium intracellulare infection in mice. When these agents were given intraperitoneally (i. p.) to mice, most of the administration protocols used in the present study failed to show a significant protective or therapeutic effect against the infection. Moreover these bacterial preparations could not exhibit a synergistic effect with minocycline in vivo. With a frequent i. p. administration of these agents, there was a tendency toward suppression of the host defense mechanisms to the infection, presumably by induction of some types of suppressor cells. Thus, it is likely that for an expression of more marked protective and/or therapeutic effects of these immunopotentiators against M intracellulare infection, the administration by routes other than i. p. is preferred.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Hiroshima University School of Medicine"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0018-2052","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00664312","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"開始ページ","attribute_value_mlt":[{"subitem_start_page":"145"}]},"item_1617187056579":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1983-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"148","bibliographicPageStart":"145","bibliographicVolumeNumber":"32","bibliographic_titles":[{"bibliographic_title":"Hiroshima Journal of Medical Sciences"},{"bibliographic_title":"Hiroshima Journal of Medical Sciences"}]}]},"item_1617258105262":{"attribute_name":"item_1617258105262","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"6408030","subitem_relation_type_select":"PMID"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"HiroshimaJMedSci_32_145.pdf","filesize":[{"value":"320.7 KB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2012855/files/HiroshimaJMedSci_32_145.pdf"},"version_id":"43443dd1-4509-4741-bb67-0f7613280576"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"38368"},"item_title":"Effects of Bacterial Immunopotentiators, LC 9018 and OK-432, on the Resistance Against Mycobacterium intracellulare Infection in Mice","item_type_id":"40003","owner":"41","path":["1730442343955"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2012855","relation_version_is_last":true,"title":["Effects of Bacterial Immunopotentiators, LC 9018 and OK-432, on the Resistance Against Mycobacterium intracellulare Infection in Mice"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-06-02T02:50:55.035166+00:00"}