| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Gastric Morphology, Gastrin and Somatostatin in Experimental Gastritis in Mice |
|
言語 |
en |
| タイトル |
|
|
タイトル |
マウス萎縮性胃炎の胃形態学，ガストリン・ソマトスタチン |
|
言語 |
ja |
| 作成者 |
Kishimoto, Shinya
Shimizu, Satoru
Yamamoto, Masahiro
Koh, Hassei
Tamaru, Takaji
Sano, Kohichi
Sumii, Kohji
Kajiyama, Goro
Miyoshi, Akima
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Experimental gastritis |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Gastrin |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Somatostatin |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
The purpose of this study was to investigate the morphological changes and endocrine profile in the gastric mucosa of mice with atrophic autoimmune gastritis induced by neonatal thymectomy. The gastritis was produced in neonatal mice [BALB/C (+/?)] of both sexes by thymectomy 3 days after birth. Of the thymectomized mice, 27.4% had marked reduction of parietal and chief cells as well as inflammatory cell infiltration, 64.1% of which had positive parietal cell antibody. Hypergastrinemia (332.0 ±231.9, control: 70.8 ± 41.3 pg/ml) was observed in mice with this type of atrophic gastritis. Mucosal concentration of antral gastrin was also increased (11.0±4.2, control: 7.25± 2.93 microgr/g) and antral G cell hyperplasia was observed in these mice (23.0±7.3, control: 12.8 ±4.7 cells/UA). Mucosal concentration of somatostatin in the body mucosa in mice with gastritis was decreased (0.598±0.391, control:0.840±0.440ng/mg) but in the antrum the concentration was almost the same as in the control (0.529±0.230 control: 0.418±0.340ng/ml). The number of body D cells was also decreased in these mice (4.0± 1.8, control: 6.1 ±0.8 cells/UA), but antral D cells were extremely few both in mice with gastritis and in control. Prematured cells and unclassified endocrine cells were increased in the body mucosa at ultrastructural levels and immunocytochemical studies did not revealed any noteworthy changes in endocrine cells such as enteric endocrine cells other than gastrin and somatostatin in mice with gastritis. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Hiroshima University School of Medicine |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
6134700 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0018-2052 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00664312 |
| 開始ページ |
|
|
開始ページ |
103 |
| 書誌情報 |
Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences
巻 32,
号 1,
p. 103-112,
発行日 1983-03
|
| 旧ID |
38365 |
HiroshimaJMedSci_32_103.pdf (1.4 MB)
