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アイテム
ラットにおけるサルファ剤の吸収におよぼす牛血清アルブミンの影響
https://hiroshima.repo.nii.ac.jp/records/2012798
https://hiroshima.repo.nii.ac.jp/records/20127987c48f0f6-cf5d-4648-bd8c-66e79c1f8435
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HiroshimaJMedSci_30_287.pdf (3.2 MB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||||
| タイトル | ||||||||||
| タイトル | EFFECT OF BOVINE SERUM ALBUMIN ON THE ABSORPTION OF SULFONAMIDES IN THE RAT | |||||||||
| 言語 | en | |||||||||
| タイトル | ||||||||||
| タイトル | ラットにおけるサルファ剤の吸収におよぼす牛血清アルブミンの影響 | |||||||||
| 言語 | ja | |||||||||
| 作成者 |
Higashi, Yutaka
× Higashi, Yutaka
× Yata, Noboru
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| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 主題 | ||||||||||
| 主題Scheme | NDC | |||||||||
| 主題 | 490 | |||||||||
| 内容記述 | ||||||||||
| 内容記述 | Effect of bovine serum albumin (BSA) on the absorption of sulfonamides was studied employing in situ recirculating perfusion method in the rat. The absorption rate constant of sulfamethoxazole was greatly decreased by addition of BSA to the perfusion solution. But, the decreasing effect of BSA on the absorption rate was diminished after removing BSA from perfusion solution. The decreasing effect of BSA on the absorption rate constant of sulfanilamide was not observed. The binding of sulfonamides to BSA was studied using an equilibrium dialysis method. Sulfamethoxazole was bound to large extent, whereas sulfanilamide was little bound. The bound fraction of sulfamethoxazole increased as the concentration of BSA increased. Influence of BSA on permeability of intestinal mucosa was not observed. Thus, the decreasing effect of BSA on the absorption rate constant of sulfamethoxazole was attributed mainly to the binding to BSA which results in the decrease of unbound drug permeable to mucosal membrane. However, experimental results were slightly deviated from the theoretical value calculated by assuming that bound drug was unabsorbed from the intestinal mucosa. | |||||||||
| 言語 | en | |||||||||
| 出版者 | ||||||||||
| 出版者 | Hiroshima University School of Medicine | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 関連情報 | ||||||||||
| 識別子タイプ | PMID | |||||||||
| 関連識別子 | 6765679 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 0018-2052 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA00664312 | |||||||||
| 開始ページ | ||||||||||
| 開始ページ | 287 | |||||||||
| 書誌情報 |
Hiroshima Journal of Medical Sciences Hiroshima Journal of Medical Sciences 巻 30, 号 4, p. 287-291, 発行日 1981-12-10 |
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| 旧ID | 38403 | |||||||||
