{"created":"2025-02-21T04:53:40.703905+00:00","id":2009358,"links":{},"metadata":{"_buckets":{"deposit":"b2dcd61e-96ab-45fe-86e1-1e6880af8777"},"_deposit":{"created_by":41,"id":"2009358","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2009358"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02009358","sets":["1730444907710"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"A Possible Mechanism of Quinolone Resistance in Vibrio anguillarum.","subitem_title_language":"en"},{"subitem_title":"Vibrio anguillarum のキノロン耐性機構","subitem_title_language":"ja"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Okuda, Jun","creatorNameLang":"en"}],"familyNames":[{"familyName":"Okuda","familyNameLang":"en"}],"givenNames":[{"givenName":"Jun","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kanamaru, Shunsuke","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kanamaru","familyNameLang":"en"}],"givenNames":[{"givenName":"Shunsuke","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yuasa, Akihiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"Yuasa","familyNameLang":"en"}],"givenNames":[{"givenName":"Akihiko","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nakaoka, Noriyoshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Nakaoka","familyNameLang":"en"}],"givenNames":[{"givenName":"Noriyoshi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kawakami, Hidemasa","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kawakami","familyNameLang":"en"}],"givenNames":[{"givenName":"Hidemasa","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nakai, Toshihiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"Nakai","familyNameLang":"en"}],"givenNames":[{"givenName":"Toshihiro","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2007 The Japanese Society of Fish Pathology"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Vibrio anguillarum","subitem_subject_scheme":"Other"},{"subitem_subject":"quinolone resistance","subitem_subject_scheme":"Other"},{"subitem_subject":"gyrA","subitem_subject_scheme":"Other"},{"subitem_subject":"parC","subitem_subject_scheme":"Other"},{"subitem_subject":"oxolinic acid","subitem_subject_scheme":"Other"},{"subitem_subject":"480","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Vibrio anguillarum のキノロン耐性機構を解明するために, DNAジャイレース遺伝子 (gyrA ) およびトポイソメラーゼIV遺伝子 (parC ) のキノロン耐性決定領域 (QRDR) 内の変異を解析した。低度耐性株ではgyrA のQRDRにのみ1塩基置換が検出された。一方, 高度耐性株ではgyrA とparC の両方のQRDRに1塩基置換が検出された。他菌種におけるキノロン耐性と同様, V. anguillarum においてもgyrA がまず変異することで低度耐性化し, 次にparC にも変異が入ることで高度耐性化すると考えられる。","subitem_description_language":"ja"},{"subitem_description":"To study a possible quinolone resistance mechanism in Vibrio anguillarum, we examined gyrA and parC mutations among the oxolinic acid-resistant strains and laboratory-derived mutants. One point mutation only in the quinolone resistance-determining region (QRDR) of the gyrA gene was detected in one strain isolated from ayu Plecoglossus altivelis and laboratory-derived mutants with low-level resistance. On the other hand, point mutations in both the gyrA and parC QRDRs were detected in one strain isolated from ayu and a laboratory-derived mutant with high-level resistance. These results suggest that as in other Gram-negative bacteria GyrA and ParC are the primary and secondary targets, respectively, of quinolone in V. anguillarum.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"日本魚病学会"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0388-788X","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"1881-7335","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AN00063165","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"73"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"75","bibliographicPageStart":"73","bibliographicVolumeNumber":"41","bibliographic_titles":[{"bibliographic_title":"魚病研究"},{"bibliographic_title":"Fish Pathology"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3147/jsfp.41.73","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.3147/jsfp.41.73","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"FishPathol_41_73.pdf","filesize":[{"value":"51.4 KB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2009358/files/FishPathol_41_73.pdf"},"version_id":"d344cd38-01b6-4ae4-895e-637e2657afb6"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"25670"},"item_title":"A Possible Mechanism of Quinolone Resistance in Vibrio anguillarum.","item_type_id":"40003","owner":"41","path":["1730444907710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2009358","relation_version_is_last":true,"title":["A Possible Mechanism of Quinolone Resistance in Vibrio anguillarum."],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-22T05:24:12.164174+00:00"}