| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Titanium ion induces necrosis and sensitivity to lipopolysaccharide in gingival epithelial-like cells |
|
言語 |
en |
| 作成者 |
Makihira, Seicho
Mine, Yuichi
Nikawa, Hiroki
Shuto, Takahiro
Iwata, Satoshi
Hosokawa, Ryuji
Kamoi, Kohei
Okazaki, Shota
Yamaguchi, Yu
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2010 Elsevier Ltd |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Titanium ion |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Cell viability |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
TLR-2 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
TLR-4 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Gingival epithelial cells |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Gingival epithelial-like cells (GE-1) were cultured and used to examine the cellular responses of gingival tissues to varying concentrations of titanium (Ti) ions. Titanium ions at concentrations of more than 13 ppm significantly decreased the viability of GE-1 cells and increased LDH release from the cells into the supernatant, but had no significant effect on their caspase 3 activity. These data suggest that a high concentration of Ti ions induced necrosis of the GE-1 cells. Titanium ions at a concentration of 5 ppm significantly increased the level of CCL2 mRNA expression in GE-1 cells exposed to lipopolysaccharide derived from Porphyromonas gingivalis in a synergistic manner. Moreover, the mRNA expression levels of TLR-4 and ICAM-1 in GE-1 cells loaded with Ti ions at 9 ppm were significantly enhanced as compared with those in GE-1 cells without Ti stimulation. We suggest that Ti ions are in part responsible for monocyte infiltration in the oral cavity by elevating the sensitivity of gingival epithelial cells to microorganisms. Taken together, these data indicate that Ti ions may be involved in cytotoxicity and inflammation at the interfaces of dental implants and gingival tissue. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Pergamon Elsevier Science Ltd |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.tiv.2010.07.023 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1016/j.tiv.2010.07.023 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0887-2333 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10678594 |
| 開始ページ |
|
|
開始ページ |
1905 |
| 書誌情報 |
Toxicology in Vitro
Toxicology in Vitro
巻 24,
号 7,
p. 1905-1910,
発行日 2010-10
|
| 旧ID |
30803 |
ToxicolVitro_24_1905.pdf (2.8 MB)
