{"created":"2025-02-21T04:40:24.057998+00:00","id":2008962,"links":{},"metadata":{"_buckets":{"deposit":"dbd9cbc4-8a24-49d0-9fd6-f683fcc272e4"},"_deposit":{"created_by":41,"id":"2008962","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2008962"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02008962","sets":["1730444907710"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"miR-22 represses cancer progression by inducing cellular senescence","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Xu, Dan","creatorNameLang":"en"}],"familyNames":[{"familyName":"Xu","familyNameLang":"en"}],"givenNames":[{"givenName":"Dan","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Takeshita, Fumitaka","creatorNameLang":"en"}],"familyNames":[{"familyName":"Takeshita","familyNameLang":"en"}],"givenNames":[{"givenName":"Fumitaka","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hino, Yumiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"Hino","familyNameLang":"en"}],"givenNames":[{"givenName":"Yumiko","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Fukunaga, Saori","creatorNameLang":"en"}],"familyNames":[{"familyName":"Fukunaga","familyNameLang":"en"}],"givenNames":[{"givenName":"Saori","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kudo, Yasusei","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kudo","familyNameLang":"en"}],"givenNames":[{"givenName":"Yasusei","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tamaki, Aya","creatorNameLang":"en"}],"familyNames":[{"familyName":"Tamaki","familyNameLang":"en"}],"givenNames":[{"givenName":"Aya","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Matsunaga, Junko","creatorNameLang":"en"}],"familyNames":[{"familyName":"Matsunaga","familyNameLang":"en"}],"givenNames":[{"givenName":"Junko","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Takahashi, Ryou-u","creatorNameLang":"en"}],"familyNames":[{"familyName":"Takahashi","familyNameLang":"en"}],"givenNames":[{"givenName":"Ryou-u","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Takata, Takashi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Takata","familyNameLang":"en"}],"givenNames":[{"givenName":"Takashi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Shimamoto, Akira","creatorNameLang":"en"}],"familyNames":[{"familyName":"Shimamoto","familyNameLang":"en"}],"givenNames":[{"givenName":"Akira","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ochiya, Takahiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"Ochiya","familyNameLang":"en"}],"givenNames":[{"givenName":"Takahiro","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tahara, Hidetoshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Tahara","familyNameLang":"en"}],"givenNames":[{"givenName":"Hidetoshi","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2011 Xu et al. This article is distributed under the terms of an Attribution-Noncommercial-Share Alike-No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution-Noncommercial-Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/)."}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Cellular senescence acts as a barrier to cancer progression, and microRNAs (miRNAs) are thought to be potential senescence regulators. However, whether senescence-associated miRNAs (SA-miRNAs) contribute to tumor suppression remains unknown. Here, we report that miR-22, a novel SA-miRNA, has an impact on tumorigenesis. miR-22 is up-regulated in human senescent fibroblasts and epithelial cells but down-regulated in various cancer cell lines. miR-22 overexpression induces growth suppression and acquisition of a senescent phenotype in human normal and cancer cells. miR-22 knockdown in presenescent fibroblasts decreased cell size, and cells became more compact. miR-22-induced senescence also decreases cell motility and inhibits cell invasion in vitro. Synthetic miR-22 delivery suppresses tumor growth and metastasis in vivo by inducing cellular senescence in a mouse model of breast carcinoma. We confirmed that CDK6, SIRT1, and Sp1, genes involved in the senescence program, are direct targets of miR-22. Our study provides the first evidence that miR-22 restores the cellular senescence program in cancer cells and acts as a tumor suppressor.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"The Rockefeller University Press"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0021-9525","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00694812","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"409"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-04-18","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"424","bibliographicPageStart":"409","bibliographicVolumeNumber":"193","bibliographic_titles":[{"bibliographic_title":"The journal of cell biology"},{"bibliographic_title":"The journal of cell biology"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1083/jcb.201010100","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1083/jcb.201010100","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"JCellBiol_193_409.pdf","filesize":[{"value":"4.0 MB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2008962/files/JCellBiol_193_409.pdf"},"version_id":"ebfac875-8242-47c0-ac45-df066991f6f8"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"32006"},"item_title":"miR-22 represses cancer progression by inducing cellular senescence","item_type_id":"40003","owner":"41","path":["1730444907710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2008962","relation_version_is_last":true,"title":["miR-22 represses cancer progression by inducing cellular senescence"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-22T04:40:13.090061+00:00"}