| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Negative Regulation of Class IA Phosphoinositide 3-kinase by Protein Kinase Cδ Limits Fcγ Receptor-mediated Phagocytosis in Macrophages |
|
言語 |
en |
| 作成者 |
Hazeki, Kaoru
Inoue, Kazumi
Nigorikawa, Kiyomi
Hazeki, Osamu
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2008 The Japanese Biochemical Society |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Akt |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Fcγreceptor |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Phagocytosis |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Phosphoinositide 3-kinase |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
PKCδ |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Stimulation of macrophages by various ligands results in the activation of both phosphoinositide 3-kinase (PI3K) and protein kinase C (PKC). Here, we showed that PKCδ selectively inhibits class IA PI3K. Prior exposure of macrophages to a PKC activator, phorbol 12-myristate 13-acetate (PMA) inhibited the PI3K activation induced by the Fcγ receptor (FcγR) ligation but not that induced by C5a. Prolonged PKC inhibition by GF109203X increased the basal PI3K activity of quiescent macrophages. The effect of the PKC inhibitor can be observed in macrophages from mice lacking class IB PI3K (p110γ). Thus PKC was suggested to selectively attenuate the class IA activity. Chronic PKC activation by PMA induced PKCδ degradation and Akt activation. Enhancement of the basal Akt actvity was also observed in cells stably deficient in PKCδ prepared by shRNA technique. FcγR-mediated phagocytosis was dramatically increased in these cells. Thus it is suggested that inactivation of class IA PI3K by PKCδ is functioning in regulation of FcγR-mediated phagocytosis. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Other Oxford University Press |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1093/jb/mvn142 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1093/jb/mvn142 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0021-924X |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00694073 |
| 開始ページ |
|
|
開始ページ |
87 |
| 書誌情報 |
The Journal of Biochemistry
The Journal of Biochemistry
巻 145,
号 1,
p. 87-94,
発行日 2009
|
| 旧ID |
25926 |
JBiochem_145_87.pdf (2.0 MB)
