{"created":"2025-02-21T04:30:54.157690+00:00","id":2008659,"links":{},"metadata":{"_buckets":{"deposit":"beac776b-4cc0-4e60-89fd-e4ffa49c0c4a"},"_deposit":{"created_by":41,"id":"2008659","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2008659"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02008659","sets":["1730444907710"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Inhibitory Effects of Pisiferic Acid on Angiogenesis and Lymphangiogenesis","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shibata, Sachi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Shibata","familyNameLang":"en"}],"givenNames":[{"givenName":"Sachi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yatagai, Mitsuyoshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Yatagai","familyNameLang":"en"}],"givenNames":[{"givenName":"Mitsuyoshi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tateishi, Yoshiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"Tateishi","familyNameLang":"en"}],"givenNames":[{"givenName":"Yoshiko","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Matubara, Kiminori","creatorNameLang":"en"}],"familyNames":[{"familyName":"Matubara","familyNameLang":"en"}],"givenNames":[{"givenName":"Kiminori","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© Georg Thieme Verlag KG Stuttgart · New York ·"},{"subitem_rights":"This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License."}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Chamaecyparis pisifera","subitem_subject_scheme":"Other"},{"subitem_subject":"Cupressaceae","subitem_subject_scheme":"Other"},{"subitem_subject":"pisiferic acid","subitem_subject_scheme":"Other"},{"subitem_subject":"angiogenesis","subitem_subject_scheme":"Other"},{"subitem_subject":"lymphangiogenesis","subitem_subject_scheme":"Other"},{"subitem_subject":"endothelial cells","subitem_subject_scheme":"Other"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Pisiferic acid, a diterpene isolated from Chamaecyparis pisifera, has a chemical structure similar to carnosic acid, which has antioxidant activity and exerts various biological effects such as antibiotic and antiangiogenic activity. However, the effect of pisiferic acid on angiogenesis, which is involved in various diseases including cancer and diabetic retinopathy, has not been elucidated. We found that pisiferic acid inhibited angiogenesis and suppressed human umbilical vein endothelial cell tube formation and proliferation but had no effect on human umbilical vein endothelial cell chemotaxis. Furthermore, in lymphangiogenesis assays, pisiferic acid inhibited lymphangiogenesis and lymphatic endothelial cell tube formation and proliferation. Together, these results suggest pisiferic acid to be a useful natural compound, such as carnosic acid, with beneficial effects on angiogenesisand lymphangiogenesis-related diseases.","subitem_description_language":"en"},{"subitem_description":"Supporting information available online at http://www.thieme-connect.de/products   This work was supported in part by grants from JSPS KAKENHI, grant numbers 22580130 and 26450159 (K.M.).","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Thieme Open"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"2509‑6656","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"2199-157X","subitem_source_identifier_type":"ISSN"}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"e31"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-08-22","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"02","bibliographicPageEnd":"e34","bibliographicPageStart":"e31","bibliographicVolumeNumber":"3","bibliographic_titles":[{"bibliographic_title":"Planta Medica International Open"},{"bibliographic_title":"Planta Medica International Open"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Planta Med Int Open 2016; 3: e31–e34"}]},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1055/s-0042-107801","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1055/s-0042-107801","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"PlantaMedicaIntOpen_3_e31.pdf","filesize":[{"value":"259.6 KB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2008659/files/PlantaMedicaIntOpen_3_e31.pdf"},"version_id":"13717c94-a71b-4a2c-9fa0-62d586c3298f"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"48182"},"item_title":"Inhibitory Effects of Pisiferic Acid on Angiogenesis and Lymphangiogenesis","item_type_id":"40003","owner":"41","path":["1730444907710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2008659","relation_version_is_last":true,"title":["Inhibitory Effects of Pisiferic Acid on Angiogenesis and Lymphangiogenesis"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-22T04:04:12.148016+00:00"}