{"created":"2025-02-21T04:07:52.438476+00:00","id":2007941,"links":{},"metadata":{"_buckets":{"deposit":"85fa03a4-688b-41b1-aa46-0121515b2099"},"_deposit":{"created_by":41,"id":"2007941","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2007941"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02007941","sets":["1730444907710"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"MMP-10/Stromelysin-2 Promotes Invasion of Head and Neck Cancer","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Deraz, Elsayed Mohamed","creatorNameLang":"en"}],"familyNames":[{"familyName":"Deraz","familyNameLang":"en"}],"givenNames":[{"givenName":"Elsayed Mohamed","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kudo, Yasusei","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kudo","familyNameLang":"en"}],"givenNames":[{"givenName":"Yasusei","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yoshida, Maki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Yoshida","familyNameLang":"en"}],"givenNames":[{"givenName":"Maki","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Obayashi, Mariko","creatorNameLang":"en"}],"familyNames":[{"familyName":"Obayashi","familyNameLang":"en"}],"givenNames":[{"givenName":"Mariko","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tsunematsu, Takaaki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Tsunematsu","familyNameLang":"en"}],"givenNames":[{"givenName":"Takaaki","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tani, Hirotaka","creatorNameLang":"en"}],"familyNames":[{"familyName":"Tani","familyNameLang":"en"}],"givenNames":[{"givenName":"Hirotaka","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Siriwardena, Samadarani B. S. M.","creatorNameLang":"en"}],"familyNames":[{"familyName":"Siriwardena","familyNameLang":"en"}],"givenNames":[{"givenName":"Samadarani B. S. M.","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kiekhaee, Mohammad Reza","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kiekhaee","familyNameLang":"en"}],"givenNames":[{"givenName":"Mohammad Reza","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Qi, Guangying","creatorNameLang":"en"}],"familyNames":[{"familyName":"Qi","familyNameLang":"en"}],"givenNames":[{"givenName":"Guangying","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Iizuka, Shinji","creatorNameLang":"en"}],"familyNames":[{"familyName":"Iizuka","familyNameLang":"en"}],"givenNames":[{"givenName":"Shinji","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ogawa, Ikuko","creatorNameLang":"en"}],"familyNames":[{"familyName":"Ogawa","familyNameLang":"en"}],"givenNames":[{"givenName":"Ikuko","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Campisi, Giuseppina","creatorNameLang":"en"}],"familyNames":[{"familyName":"Campisi","familyNameLang":"en"}],"givenNames":[{"givenName":"Giuseppina","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Muzio, Lorenzo Lo","creatorNameLang":"en"}],"familyNames":[{"familyName":"Muzio","familyNameLang":"en"}],"givenNames":[{"givenName":"Lorenzo Lo","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Abiko, Yoshimitsu","creatorNameLang":"en"}],"familyNames":[{"familyName":"Abiko","familyNameLang":"en"}],"givenNames":[{"givenName":"Yoshimitsu","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kikuchi, Akira","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kikuchi","familyNameLang":"en"}],"givenNames":[{"givenName":"Akira","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Takata, Takashi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Takata","familyNameLang":"en"}],"givenNames":[{"givenName":"Takashi","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"(c) 2011 Deraz et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited."}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Background: Periostin, IFN-induced transmembrane protein 1 (IFITM1) and Wingless-type MMTV integration site family, member 5B (Wnt-5b) were previously identified as the invasion promoted genes of head and neck squamous cell carcinoma (HNSCC) by comparing the gene expression profiles between parent and a highly invasive clone. We have previously reported that Periostin and IFITM1 promoted the invasion of HNSCC cells. Here we demonstrated that Wnt-5b overexpression promoted the invasion of HNSCC cells. Moreover, stromelysin-2 (matrix metalloproteinase-10; MMP-10) was identified as a common up-regulated gene among Periostin, IFITM1 and Wnt-5b overexpressing HNSCC cells by using microarray data sets. In this study, we investigated the roles of MMP-10 in the invasion of HNSCC.     Methods and Findings: We examined the expression of MMP-10 in HNSCC cases by immunohistochemistry. High expression of MMP-10 was frequently observed and was significantly correlated with the invasiveness and metastasis in HNSCC cases. Next, we examined the roles of MMP-10 in the invasion of HNSCC cells in vitro. Ectopic overexpression of MMP-10 promoted the invasion of HNSCC cells, and knockdown of MMP-10 suppressed the invasion of HNSCC cells. Moreover, MMP-10 knockdown suppressed Periostin and Wnt-5b-promoted invasion. Interestingly, MMP-10 overexpression induced the decreased p38 activity and MMP-10 knockdown induced the increased p38 activity. In addition, treatment with a p38 inhibitor SB203580 in HNSCC cells inhibited the invasion.     Conclusions: These results suggest that MMP-10 plays an important role in the invasion and metastasis of HNSCC, and that invasion driven by MMP-10 is partially associated with p38 MAPK inhibition. We suggest that MMP-10 can be used as a marker for prediction of metastasis in HNSCC.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Public Library of Science"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"1932-6203","subitem_source_identifier_type":"ISSN"}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"e25438"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageStart":"e25438","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"PLoS ONE"},{"bibliographic_title":"PLoS ONE"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1371/journal.pone.0025438","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1371/journal.pone.0025438","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"PLoS-One_6_e25438.pdf","filesize":[{"value":"2.8 MB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2007941/files/PLoS-One_6_e25438.pdf"},"version_id":"a4303631-1993-413b-9bdb-10c7d4a933ee"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"34758"},"item_title":"MMP-10/Stromelysin-2 Promotes Invasion of Head and Neck Cancer","item_type_id":"40003","owner":"41","path":["1730444907710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2007941","relation_version_is_last":true,"title":["MMP-10/Stromelysin-2 Promotes Invasion of Head and Neck Cancer"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-22T02:56:04.201491+00:00"}