{"created":"2025-02-21T04:06:42.332340+00:00","id":2007903,"links":{},"metadata":{"_buckets":{"deposit":"a0dade7f-f1ad-45c9-b348-aa1a6a888b43"},"_deposit":{"created_by":41,"id":"2007903","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2007903"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02007903","sets":["1730444907710"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Decrease in size of azoxymethane induced colon carcinoma in F344 rats by 180-day fermented miso","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ohuchi, Yoshie","creatorNameLang":"en"}],"familyNames":[{"familyName":"Ohuchi","familyNameLang":"en"}],"givenNames":[{"givenName":"Yoshie","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Myojin, Yuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Myojin","familyNameLang":"en"}],"givenNames":[{"givenName":"Yuki","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Shimamoto, Fumio","creatorNameLang":"en"}],"familyNames":[{"familyName":"Shimamoto","familyNameLang":"en"}],"givenNames":[{"givenName":"Fumio","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kashimoto, Naoki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kashimoto","familyNameLang":"en"}],"givenNames":[{"givenName":"Naoki","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kamiya, Kenji","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kamiya","familyNameLang":"en"}],"givenNames":[{"givenName":"Kenji","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Watanabe, Hiromitsu","creatorNameLang":"en"}],"familyNames":[{"familyName":"Watanabe","familyNameLang":"en"}],"givenNames":[{"givenName":"Hiromitsu","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2005 Spandidos Publications Ltd."}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"miso","subitem_subject_scheme":"Other"},{"subitem_subject":"colon cancer prevention","subitem_subject_scheme":"Other"},{"subitem_subject":"azoxymethane","subitem_subject_scheme":"Other"},{"subitem_subject":"F344 rat","subitem_subject_scheme":"Other"},{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"The present study was designed to investigate the effects of fermented miso (fermented soybean paste) on the induction of colon tumors by azoxymethane (AOM) in male F344 rats. A total of 91 rats, 6 weeks of age, were divided into 5 groups and given weekly subcutaneous injections of AOM (15 mg/kg body wt) for 3 weeks. The animals were placed on diets one week before the first AOM dose: commercial normal control MF diet or a diet containing 10% 2-year, 180-day fermented, or 3-4-day fermented miso. There were no differences in body and organ weights, and no aberrant crypt foci (ACF) among carcinogen-treated groups at week 25. The rates of tumor incidence were 45%, 85%, 75% and 60% with the 2-year, 180-day, and 3-4-day fermented miso and MF, respectively, and those for colon tumors were 34%, 55%, 60% and 55%, respectively. The size of well-differentiated adenocarcinomas and total (well differentiated and signet ring cell) adenocarcinomas in the 180-day fermented miso group was significantly smaller than that in the 2-year fermented miso and MF+AOM groups. Nuclear staining of beta-catenin in colon tumors was increased for the 3-4-day fermented miso compared to the 180-day fermented miso. Cdx2 staining tendency was decreased in colon tumors and adenocarcinomas compared to normal mucosa and ACF, which stained in 100% of cases. In addition, the PCNA index was significantly reduced in the 180-day group compared with those groups receiving the 3-4-day fermented miso and MF diet. The germinal region was also decreased. The present results indicate that dietary supplementation with 180-day fermented dietary miso could act as a chemopreventive agent for colon carcinogenesis.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Spandidos Publications Ltd."}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"1021-335X","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11016405","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"1559"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"1564","bibliographicPageStart":"1559","bibliographicVolumeNumber":"14","bibliographic_titles":[{"bibliographic_title":"Oncology Reports"},{"bibliographic_title":"Oncology Reports"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"OncolRep_14_1559.pdf","filesize":[{"value":"77.9 KB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2007903/files/OncolRep_14_1559.pdf"},"version_id":"d9247f60-d84b-4c74-abb3-b2b854ad2c10"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"31172"},"item_title":"Decrease in size of azoxymethane induced colon carcinoma in F344 rats by 180-day fermented miso","item_type_id":"40003","owner":"41","path":["1730444907710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2007903","relation_version_is_last":true,"title":["Decrease in size of azoxymethane induced colon carcinoma in F344 rats by 180-day fermented miso"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-21T11:10:36.604085+00:00"}