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The mapped pattern of kainate on blood pressure responses is similar to that of L-proline in the ventrolateral medulla of the rat
https://hiroshima.repo.nii.ac.jp/records/2007780
https://hiroshima.repo.nii.ac.jp/records/2007780cc65b04d-c001-464a-83b7-ad48375fae24
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
NeursciLett_425_12.pdf (271.2 KB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||
| タイトル | ||||||||
| タイトル | The mapped pattern of kainate on blood pressure responses is similar to that of L-proline in the ventrolateral medulla of the rat | |||||||
| 言語 | en | |||||||
| 作成者 |
Takemoto, Yumi
× Takemoto, Yumi
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| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 権利情報 | ||||||||
| 権利情報 | Copyright(c) 2007 Elsevier Ireland Ltd | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | kainate | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | l-proline | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | amino acid | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | ventrolateral medulla | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | arterial blood pressure | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | rat | |||||||
| 主題 | ||||||||
| 主題Scheme | NDC | |||||||
| 主題 | 490 | |||||||
| 内容記述 | ||||||||
| 内容記述 | Kainate is an excitatory amino acid receptor agonist with a structure similar to the amino acid L-proline. Our previous studies demonstrated that microinjections of L-proline into the ventrolateral medulla (VLM) of the rat induce a mapped pattern of blood pressure responses distinct from L-glutamate, and the depressor response to L-proline in the caudal VLM (CVLM) is abolished by the kainate/AMPA receptor antagonist CNQX. The present study investigated whether kainate produces the L-proline-mapped pattern of responses in the VLM, compared with the pattern by AMPA. Kainate is known to activate AMPA receptors at higher concentrations. Therefore, responses to kainate were investigated at a low concentration. Microinjections of AMPA or NMDA showed the pattern of the L-glutamate-type; a pressor response in the rostral VLM and caudal pressor area (CPA) and a depressor response in the CVLM. Microinjections of kainate showed depressor responses in the CVLM but minor pressor responses in the rostral VLM, suggesting the same responses to L-proline. However, the response sites in the CPA did not enable us to clearly determine the L-proline-type. Further trials at sites defined by a pressor response to L-glutamate in the CPA, successive injections Of L-proline and kainate produced no response, indicating that L-glutamate responding neurons in the CPA are not sensitive to L-proline and kainate. These results suggest that kainate stimulation in the VLM produces a mapped pattern of ABP responses similar to the mapped pattern with L-proline. Kainate receptors could therefore be involved in the depressor response to L-proline in the medulla. | |||||||
| 言語 | en | |||||||
| 出版者 | ||||||||
| 出版者 | Elsevier Ireland Ltd | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | AO | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_b1a7d7d4d402bcce | |||||||
| 関連情報 | ||||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.1016/j.neulet.2007.08.003 | |||||||
| 関連情報 | ||||||||
| 関連タイプ | isVersionOf | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | http://dx.doi.org/10.1016/j.neulet.2007.08.003 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 0304-3940 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AA00754925 | |||||||
| 開始ページ | ||||||||
| 開始ページ | 12 | |||||||
| 書誌情報 |
Neuroscience Letters Neuroscience Letters 巻 425, 号 1, p. 12-17, 発行日 2007-09 |
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| 旧ID | 21471 | |||||||
