{"created":"2025-02-21T04:02:34.222440+00:00","id":2007773,"links":{},"metadata":{"_buckets":{"deposit":"8179504a-7f9f-44e2-8bad-ec3dd46cc7e9"},"_deposit":{"created_by":41,"id":"2007773","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2007773"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02007773","sets":["1730444907710"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Phosphorylation of TRPV1 by neurokinin-1 receptor agonist exaggerates the capsaicin-mediated substance P release from cultured rat dorsal root ganglion neurons","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tang, He-Bin","creatorNameLang":"en"}],"familyNames":[{"familyName":"Tang","familyNameLang":"en"}],"givenNames":[{"givenName":"He-Bin","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Li, Yu-Sang","creatorNameLang":"en"}],"familyNames":[{"familyName":"Li","familyNameLang":"en"}],"givenNames":[{"givenName":"Yu-Sang","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Miyano, Kanako","creatorNameLang":"en"}],"familyNames":[{"familyName":"Miyano","familyNameLang":"en"}],"givenNames":[{"givenName":"Kanako","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nakata, Yoshihiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"Nakata","familyNameLang":"en"}],"givenNames":[{"givenName":"Yoshihiro","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2009 Elsevier B.V."}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Dorsal root ganglion neuron","subitem_subject_scheme":"Other"},{"subitem_subject":"Neurokinin-1 receptor","subitem_subject_scheme":"Other"},{"subitem_subject":"Phosphorylation of transient receptor potential vanilloid receptor subtype 1","subitem_subject_scheme":"Other"},{"subitem_subject":"Substance P release","subitem_subject_scheme":"Other"},{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"The present study was conducted to determine whether the activation of neurokinin-1 receptor (NK-1R) by its agonist (GR73632) enhances the capsaicin-evoked substance P (SP) release using a radioimmunoassay. A pre-exposure to GR73632 enhanced the capsaicin-evoked SP release in a time- and dose-dependent manner. The augmentation of capsaicin-evoked SP release by GR73632 was completely inhibited by pharmacological blockade of NK-1R or transient receptor potential vanilloid receptor subtype 1 (TRPV1), and was partially attenuated by the inhibition of either protein kinase C (PKC), cyclooxygenase (COX) or phospholipase C (PLC), p38 or p42/44 mitogen-activated protein (MAP) kinase, but not protein kinase A. This augmentation of SP release was further increased by inhibition of c-Jun NH2-terminal kinase. A short-term (10 min) exposure to GR73632 resulted in an increase in the TRPV1 phosphorylation. The increase in the TRPV1 phosphorylated forms induced by a 60-min exposure to GR73632 was completely abolished by the inhibition of either PKC, COX or PLC, p38 or p42/44 MAP kinases. Immunocytochemistry study demonstrated that the NK-1R and TRPV1 were mainly co-expressed in the small-sized neurons. These findings suggest that the activation of NK-1R by its agonist, by sensitizing the TRPV1 through the PKC phosphorylation of TRPV1, may play a role in the enhancement of the capsaicin-evoked SP release from cultured rat DRG neurons.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Pergamon-Elsevier Science Ltd."}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0028-3908","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00754812","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"1405"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"1411","bibliographicPageStart":"1405","bibliographicVolumeNumber":"55","bibliographic_titles":[{"bibliographic_title":"Neuropharmacology"},{"bibliographic_title":"Neuropharmacology"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_b1a7d7d4d402bcce","subitem_version_type":"AO"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.neuropharm.2008.08.037","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1016/j.neuropharm.2008.08.037","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"Neuropharmacology_55_1405.pdf","filesize":[{"value":"225.4 KB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2007773/files/Neuropharmacology_55_1405.pdf"},"version_id":"6629615e-46a9-4b41-918f-ed531431915f"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"25915"},"item_title":"Phosphorylation of TRPV1 by neurokinin-1 receptor agonist exaggerates the capsaicin-mediated substance P release from cultured rat dorsal root ganglion neurons","item_type_id":"40003","owner":"41","path":["1730444907710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2007773","relation_version_is_last":true,"title":["Phosphorylation of TRPV1 by neurokinin-1 receptor agonist exaggerates the capsaicin-mediated substance P release from cultured rat dorsal root ganglion neurons"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-21T10:57:05.877124+00:00"}