{"created":"2025-02-21T04:01:50.457165+00:00","id":2007749,"links":{},"metadata":{"_buckets":{"deposit":"949b0d41-8a6e-4d1d-b8cf-20f5ca89340d"},"_deposit":{"created_by":41,"id":"2007749","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2007749"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02007749","sets":["1730444907710"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Action-at-a-distance mutations induced by 8-oxo-7,8-dihydroguanine are dependent on APOBEC3","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Fukushima, Ruriko","creatorNameLang":"en"}],"familyNames":[{"familyName":"Fukushima","familyNameLang":"en"}],"givenNames":[{"givenName":"Ruriko","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Suzuki, Tetsuya","creatorNameLang":"en"}],"familyNames":[{"familyName":"Suzuki","familyNameLang":"en"}],"givenNames":[{"givenName":"Tetsuya","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kobayakawa, Akari","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kobayakawa","familyNameLang":"en"}],"givenNames":[{"givenName":"Akari","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kamiya, Hiroyuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kamiya","familyNameLang":"en"}],"givenNames":[{"givenName":"Hiroyuki","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"This is a pre-copyedited, author-produced version of an article accepted for publication in Mutagenesis following peer review. The version of record Mutagenesis, Volume 39, Issue 1, January 2024, Pages 24–31 is available online at: https://doi.org/10.1093/mutage/gead023.","subitem_rights_language":"en"},{"subitem_rights":"This is not the published version. Please cite only the published version.","subitem_rights_language":"en"},{"subitem_rights":"この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。","subitem_rights_language":"ja"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"8-oxo-7","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"8-dihydroguanine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"8-hydroxyguanine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"action-at-a-distance mutation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"APOBEC3","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cytosine deaminase","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"DNA oxidation is a serious threat to genome integrity and is involved in mutations and cancer initiation. The G base is most frequently damaged, and 8-oxo-7,8-dihydroguanine (GO, 8-hydroxyguanine) is one of the predominant damaged bases. In human cells, GO causes a G:C→T:A transversion mutation at the modified site, and also induces untargeted substitution mutations at the G bases of 5ʹ-GpA-3ʹ dinucleotides (action-at-a-distance mutations). The 5ʹ-GpA-3ʹ sequences are complementary to the 5ʹ-TpC-3ʹ sequences, the preferred substrates for apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3 (APOBEC3) cytosine deaminases, and thus their contribution to mutagenesis has been considered. In this study, APOBEC3B, the most abundant APOBEC3 protein in human U2OS cells, was knocked down in human U2OS cells, and a GO-shuttle plasmid was then transfected into the cells. The action-at-a-distance mutations were reduced to ~25% by the knockdown, indicating that GO-induced action-at-a-distance mutations are highly dependent on APOBEC3B in this cell line.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Oxford","subitem_publisher_language":"en"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186901218":{"attribute_name":"Funding Reference","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"19H04278","subitem_award_uri":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-19H04278/"},"subitem_award_titles":[{"subitem_award_title":"損傷塩基が誘発する遠隔作用変異：損傷部位から離れた塩基に生じる変異の生成機構","subitem_award_title_language":"ja"}],"subitem_funder_names":[{"subitem_funder_name":"日本学術振興会","subitem_funder_name_language":"ja"}]},{"subitem_award_numbers":{"subitem_award_number":"22H03751","subitem_award_uri":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-23K25005/"},"subitem_award_titles":[{"subitem_award_title":"Molecular mechanisms of action-at-a-distance mutations induced by DNA damage","subitem_award_title_language":"ja"}],"subitem_funder_names":[{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]},{"subitem_award_numbers":{"subitem_award_number":"20K12181","subitem_award_uri":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-20K12181/"},"subitem_award_titles":[{"subitem_award_title":"活性酸素と脱アミノ化酵素APOBEC3が誘発する遠隔作用変異の分子機構の解明","subitem_award_title_language":"ja"}],"subitem_funder_names":[{"subitem_funder_name":"日本学術振興会","subitem_funder_name_language":"ja"}]},{"subitem_award_numbers":{"subitem_award_number":"JPMJSP2132"},"subitem_award_titles":[{"subitem_award_title":"活性酸素と脱アミノ化酵素APOBEC3が誘発する遠隔作用変異の分子機構の解明","subitem_award_title_language":"ja"}],"subitem_funder_names":[{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]},{"subitem_award_titles":[{"subitem_award_title":"DNAポリメラーゼζ（ゼータ）が関与する内在的DNA構造と変異誘発の分子機構","subitem_award_title_language":"ja"}],"subitem_funder_names":[{"subitem_funder_name":"日本学術振興会","subitem_funder_name_language":"ja"}]},{"subitem_award_titles":[{"subitem_award_title":"Mutagenesis by translesion synthesis bypass endogenous DNA structures by DNA polymerase zeta","subitem_award_title_language":"ja"}],"subitem_funder_names":[{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]},{"subitem_award_titles":[{"subitem_award_title":"広島大学創発的 次世代 研究者育成・支援プログラム"}],"subitem_funder_names":[{"subitem_funder_name":"科学技術振興機構","subitem_funder_name_language":"ja"}]},{"subitem_award_titles":[{"subitem_award_title":"広島大学創発的 次世代 研究者育成・支援プログラム"}],"subitem_funder_names":[{"subitem_funder_name":"Japan Science and Technology Agency","subitem_funder_name_language":"en"}]}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"24"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-07-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"31","bibliographicPageStart":"24","bibliographicVolumeNumber":"39","bibliographic_titles":[{"bibliographic_title":"Mutagenesis","bibliographic_titleLang":"en"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1093/mutage/gead023","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-12-18"}],"displaytype":"simple","filename":"Mutagenesis_39_24.pdf","filesize":[{"value":"365.6 KB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2007749/files/Mutagenesis_39_24.pdf"},"version_id":"f0770b6b-1b48-4c68-bd37-892c2e026328"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"55877"},"item_title":"Action-at-a-distance mutations induced by 8-oxo-7,8-dihydroguanine are dependent on APOBEC3","item_type_id":"40003","owner":"41","path":["1730444907710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-12-18"},"publish_date":"2024-12-18","publish_status":"0","recid":"2007749","relation_version_is_last":true,"title":["Action-at-a-distance mutations induced by 8-oxo-7,8-dihydroguanine are dependent on APOBEC3"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-21T10:51:23.613117+00:00"}