{"created":"2025-02-21T04:01:14.407254+00:00","id":2007729,"links":{},"metadata":{"_buckets":{"deposit":"5ddd0451-5c29-41a4-8036-9465db3a98ff"},"_deposit":{"created_by":41,"id":"2007729","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2007729"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02007729","sets":["1730444907710"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Protein kinase Cδ binds TIRAP/Mal to participate in TLR signaling","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kubo-Murai, Miho","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kubo-Murai","familyNameLang":"en"}],"givenNames":[{"givenName":"Miho","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hazeki, Kaoru","creatorNameLang":"en"}],"familyNames":[{"familyName":"Hazeki","familyNameLang":"en"}],"givenNames":[{"givenName":"Kaoru","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sukenobu, Naoe","creatorNameLang":"en"}],"familyNames":[{"familyName":"Sukenobu","familyNameLang":"en"}],"givenNames":[{"givenName":"Naoe","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yoshikawa, Kyoko","creatorNameLang":"en"}],"familyNames":[{"familyName":"Yoshikawa","familyNameLang":"en"}],"givenNames":[{"givenName":"Kyoko","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nigorikawa, Kiyomi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Nigorikawa","familyNameLang":"en"}],"givenNames":[{"givenName":"Kiyomi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Inoue, Kazumi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Inoue","familyNameLang":"en"}],"givenNames":[{"givenName":"Kazumi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yamamoto, Toshiyoshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Yamamoto","familyNameLang":"en"}],"givenNames":[{"givenName":"Toshiyoshi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Matsumoto, Misako","creatorNameLang":"en"}],"familyNames":[{"familyName":"Matsumoto","familyNameLang":"en"}],"givenNames":[{"givenName":"Misako","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Seya, Tsukasa","creatorNameLang":"en"}],"familyNames":[{"familyName":"Seya","familyNameLang":"en"}],"givenNames":[{"givenName":"Tsukasa","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Inoue, Norimitsu","creatorNameLang":"en"}],"familyNames":[{"familyName":"Inoue","familyNameLang":"en"}],"givenNames":[{"givenName":"Norimitsu","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hazeki, Osamu","creatorNameLang":"en"}],"familyNames":[{"familyName":"Hazeki","familyNameLang":"en"}],"givenNames":[{"givenName":"Osamu","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2006 Elsevier Ltd"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"PKCδ","subitem_subject_scheme":"Other"},{"subitem_subject":"TLR","subitem_subject_scheme":"Other"},{"subitem_subject":"macrophage","subitem_subject_scheme":"Other"},{"subitem_subject":"signal transduction","subitem_subject_scheme":"Other"},{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Toll-like receptor (TLR) family members recognize specific molecular patterns within pathogens. Signaling through TLRs results in a proximal event that involves direct binding of adaptor proteins to the receptors. We observed that TIRAP/Mal, an adaptor protein for TLR2 and TLR4, binds protein kinase Cδ (PKCδ). TIRAP/Mal GST-fusion protein and a TIRAP/Mal antibody were able to precipitate PKCδ from rat peritoneal macrophage and THP1 cell lysates. Truncation mutants of TIRAP/Mal showed that the TIR domain of TIRAP/Mal is responsible for binding. TLR2- and TLR4-mediated phosphorylation of p38 MAPK, IKK, and IκB in RAW264.7 cells were abolished by depletion of PKCδ. These results suggest that PKCδ binding to TIRAP/Mal promotes TLR signaling events.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Pergamon-Elsevier Science Ltd."}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0161-5890","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00307483","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"2257"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"2264","bibliographicPageStart":"2257","bibliographicVolumeNumber":"44","bibliographic_titles":[{"bibliographic_title":"Molecular Immunology"},{"bibliographic_title":"Molecular Immunology"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_b1a7d7d4d402bcce","subitem_version_type":"AO"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.molimm.2006.11.005","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"17161867","subitem_relation_type_select":"PMID"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1016/j.molimm.2006.11.005","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"MolImmunol_44-9_2257.pdf","filesize":[{"value":"1.4 MB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2007729/files/MolImmunol_44-9_2257.pdf"},"version_id":"5540cfba-0c14-4f84-90a2-0b5322b4e773"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"20576"},"item_title":"Protein kinase Cδ binds TIRAP/Mal to participate in TLR signaling","item_type_id":"40003","owner":"41","path":["1730444907710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2007729","relation_version_is_last":true,"title":["Protein kinase Cδ binds TIRAP/Mal to participate in TLR signaling"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-21T10:49:23.719335+00:00"}