{"created":"2025-02-21T04:01:03.474020+00:00","id":2007723,"links":{},"metadata":{"_buckets":{"deposit":"b9843e47-4377-40ef-a8b1-3c5a9ad5d7af"},"_deposit":{"created_by":41,"id":"2007723","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2007723"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02007723","sets":["1730444907710"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Nuclear IKKβ Is an Adaptor Protein for IκBα Ubiquitination and Degradation in UV-Induced NF-κB Activation","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tsuchiya, Yoshihiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"Tsuchiya","familyNameLang":"en"}],"givenNames":[{"givenName":"Yoshihiro","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Asano, Tomoichiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"Asano","familyNameLang":"en"}],"givenNames":[{"givenName":"Tomoichiro","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nakayama, Keiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"Nakayama","familyNameLang":"en"}],"givenNames":[{"givenName":"Keiko","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kato,  Tomohisa, Jr","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kato","familyNameLang":"en"}],"givenNames":[{"givenName":" Tomohisa, Jr","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Karin, Michael","creatorNameLang":"en"}],"familyNames":[{"familyName":"Karin","familyNameLang":"en"}],"givenNames":[{"givenName":"Michael","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kamata, Hideaki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kamata","familyNameLang":"en"}],"givenNames":[{"givenName":"Hideaki","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2010 Elsevier Inc."}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"SIGNALING","subitem_subject_scheme":"Other"},{"subitem_subject":"CELLCYCLE","subitem_subject_scheme":"Other"},{"subitem_subject":"PROTEINS","subitem_subject_scheme":"Other"},{"subitem_subject":"460","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Proinflammatory cytokines activate NF-κB using the IκB kinase (IKK) complex that phosphorylates inhibitory proteins (IκBs) at N-terminal sites resulting in their ubiquitination and degradation in the cytoplasm. Although ultraviolet (UV) irradiation does not lead to IKK activity, it activates NF-κB by an unknown mechanism through IκBα degradation without N-terminal phosphorylation. Here, we describe an adaptor function of nuclear IKKβ in UV-induced IκBα degradation. UV irradiation induces the nuclear translocation of IκBα and association with IKKβ, which constitutively interacts with β-TrCP through heterogeneous ribonucleoprotein-U (hnRNP-U) leading to IκBα ubiquitination and degradation. Furthermore, casein kinase 2 (CK2) and p38 associate with IKKβ and promote IκBα degradation by phosphorylation at C-terminal sites. Thus, nuclear IKKβ acts as an adaptor protein for IκBα degradation in UV-induced NF-κB activation. NF-κB activated by the nuclear IKKβ adaptor protein suppresses anti-apoptotic gene expression and promotes UV-induced cell death.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Cell Press"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"1097-2765","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA1119005X","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"570"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-08-27","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"582","bibliographicPageStart":"570","bibliographicVolumeNumber":"39","bibliographic_titles":[{"bibliographic_title":"Molecular Cell"},{"bibliographic_title":"Molecular Cell"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_b1a7d7d4d402bcce","subitem_version_type":"AO"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.molcel.2010.07.030","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1016/j.molcel.2010.07.030","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"MolCell_39_570.pdf","filesize":[{"value":"1.5 MB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2007723/files/MolCell_39_570.pdf"},"version_id":"f2b2a8d8-8c65-4045-8a03-3185854cb22b"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"30789"},"item_title":"Nuclear IKKβ Is an Adaptor Protein for IκBα Ubiquitination and Degradation in UV-Induced NF-κB Activation","item_type_id":"40003","owner":"41","path":["1730444907710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2007723","relation_version_is_last":true,"title":["Nuclear IKKβ Is an Adaptor Protein for IκBα Ubiquitination and Degradation in UV-Induced NF-κB Activation"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-21T10:48:51.249281+00:00"}