{"created":"2025-02-21T04:01:00.290016+00:00","id":2007722,"links":{},"metadata":{"_buckets":{"deposit":"effb7013-a0b2-4f59-8ade-e87135776d9c"},"_deposit":{"created_by":41,"id":"2007722","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2007722"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02007722","sets":["1730444907710"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Cytokines direct the regulation of Bim and p27^KIP1 mRNA stability by Heat shock cognate protein 70","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsui, Hirotaka","creatorNameLang":"en"}],"familyNames":[{"familyName":"Matsui","familyNameLang":"en"}],"givenNames":[{"givenName":"Hirotaka","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Asou, Hiroya","creatorNameLang":"en"}],"familyNames":[{"familyName":"Asou","familyNameLang":"en"}],"givenNames":[{"givenName":"Hiroya","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Inaba, Toshiya","creatorNameLang":"en"}],"familyNames":[{"familyName":"Inaba","familyNameLang":"en"}],"givenNames":[{"givenName":"Toshiya","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2007 Elsevier Ltd."}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"RNA","subitem_subject_scheme":"Other"},{"subitem_subject":"SIGNALING","subitem_subject_scheme":"Other"},{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Previous gene-targeting studies indicated that Bim, a BIB-only death activator, and p27^KIP1, a cydin-dependent kinase inhibitor, regulate total cell number in the body. Cytokines contribute to this process primarily by negatively regulating the steady-state levels of Bim and p27 mRNAs. Here we present a novel mechanism for cytokine-mediated post-transcriptional regulation of Bim and p27 mRNA levels via the activity of Heat shock cognate protein 70 (Hsc70), which enhances the stability of specific mRNAs by binding to AU-rich elements (AREs) in their 3' -untranslated regions. The RNA-binding potential of Hsc70 is regulated by co-chaperones, including Bag-4 (also SODD), CHIP, Hip and Hsp40. Cytokines that down-regulate Bim and p27 operate via Ras-activated signaling pathways, which in turn control the expression or function of these co-chaperones. Thus, exposure of cells to cytokines ultimately leads to the destabilization of Bim and p27 mRNAs and the promotion of cell division and survival. This unanticipated role for a chaperone/co-chaperone complex in the control of mRNA stability appears to be critical for hematopoiesis and leukemogenesis.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"1097-2765","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA1119005X","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"99"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-01-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"112","bibliographicPageStart":"99","bibliographicVolumeNumber":"25","bibliographic_titles":[{"bibliographic_title":"Molecular Cell"},{"bibliographic_title":"Molecular Cell"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_b1a7d7d4d402bcce","subitem_version_type":"AO"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.molcel.2006.12.007","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1016/j.molcel.2006.12.007","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"MolCell_25_99.pdf","filesize":[{"value":"2.8 MB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2007722/files/MolCell_25_99.pdf"},"version_id":"87e68233-55fa-4e7b-a07b-db648df39b6d"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"21549"},"item_title":"Cytokines direct the regulation of Bim and p27^KIP1 mRNA stability by Heat shock cognate protein 70","item_type_id":"40003","owner":"41","path":["1730444907710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2007722","relation_version_is_last":true,"title":["Cytokines direct the regulation of Bim and p27^KIP1 mRNA stability by Heat shock cognate protein 70"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-21T10:48:45.202306+00:00"}