| アイテムタイプ |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Regulation of the Spontaneous Augmentation of Na_V1.9 in Mouse Dorsal Root Ganglion Neurons : Effect of PKA and PKC Pathways |
|
言語 |
en |
| 作成者 |
Kakimura, Jun-ichi
Zheng, Taixing
Uryu, Noriko
Ogata, Nobukuni
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Na+ channel |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Tetrodotoxin |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
dorsal root ganglion |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
patch clamp |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
PKA |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
PKC |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Sensory neurons in the dorsal root ganglion express two kinds of tetrodotoxin resistant (TTX-R) isoforms of voltage-gated sodium channels, NaV1.8 and NaV1.9. These isoforms play key roles in the pathophysiology of chronic pain. Of special interest is NaV1.9: our previous studies revealed a unique property of the NaV1.9 current, i.e., the NaV1.9 current shows a gradual and notable up-regulation of the peak amplitude during recording ("spontaneous augmentation of NaV1.9"). However, the mechanism underlying the spontaneous augmentation of NaV1.9 is still unclear. In this study, we examined the effects of protein kinases A and C (PKA and PKC), on the spontaneous augmentation of NaV1.9. The spontaneous augmentation of the NaV1.9 current was significantly suppressed by activation of PKA, whereas activation of PKA did not affect the voltage dependence of inactivation for the NaV1.9 current. On the contrary, the finding that activation of PKC can affect the voltage dependence of inactivation for NaV1.9 in the perforated patch recordings,where the augmentation does not occur, suggests that the effects of PMA are independent of the augmentation process. These results indicate that the spontaneous augmentation of NaV1.9 was regulated directly by PKA, and indirectly by PKC. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Molecular Diversity Preservation International-MDPI |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.3390/md8030728 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.3390/md8030728 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1660-3397 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA1203626X |
| 開始ページ |
|
|
開始ページ |
728 |
| 書誌情報 |
Marine Drugs
Marine Drugs
巻 8,
号 3,
p. 728-740,
発行日 2010
|
| 旧ID |
30128 |
MarDrugs_8_728.pdf (221.7 KB)
